loading...| Preferred Name |
cannabinol |
|
| Synonyms |
3-amyl-1-hydroxy-6,6,9-trimethyl-6H-dibenzo(b,d)pyran |
|
| Definitions |
A cannabinoid isolated from the plant Cannabis that is a metabolite of tetrahydrocannabinol (THC), with potential immunosuppressive and anti-inflammatory activities. Cannabinol preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells. Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84510" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84510" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000750101 |
|
| altLabel |
3-amyl-1-hydroxy-6,6,9-trimethyl-6H-dibenzo(b,d)pyran |
|
| CAS Registry |
521-35-7 |
|
| cui |
C0006865 |
|
| DATE FIRST PUBLISHED |
2013-06-03 |
|
| Date last modified |
2013-06-03 |
|
| definition |
A cannabinoid isolated from the plant Cannabis that is a metabolite of tetrahydrocannabinol (THC), with potential immunosuppressive and anti-inflammatory activities. Cannabinol preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells. Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84510" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84510" NCI Thesaurus) |
|
| NCI ID |
C84510 |
|
| notation |
CDR0000750101 |
|
| NSC Code |
134455 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cannabinol |
|
| tui |
T109 T121 |