loading...| Preferred Name |
vecuronium bromide |
|
| Synonyms |
piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl)-1-methyl-, bromide |
|
| Definitions |
The bromide salt form of vecuronium, a synthetic steroid derivative of the naturally occurring alkaloids of curare with a muscle relaxant property. Vecuronium bromide competes with acetylcholine for the nicotinic receptors at the neuromuscular junction of skeletal muscles, thereby inhibiting the action of acetylcholine and blocking the neural transmission without depolarizing the postsynaptic membrane. This leads to skeletal muscle relaxation and paralysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47782" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47782" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000740778 |
|
| altLabel |
piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl)-1-methyl-, bromide Norcuron NC-45 |
|
| CAS Registry |
50700-72-6 |
|
| cui |
C0042435 C0733720 C0700018 |
|
| DATE FIRST PUBLISHED |
2012-09-28 |
|
| Date last modified |
2012-09-27 |
|
| definition |
The bromide salt form of vecuronium, a synthetic steroid derivative of the naturally occurring alkaloids of curare with a muscle relaxant property. Vecuronium bromide competes with acetylcholine for the nicotinic receptors at the neuromuscular junction of skeletal muscles, thereby inhibiting the action of acetylcholine and blocking the neural transmission without depolarizing the postsynaptic membrane. This leads to skeletal muscle relaxation and paralysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47782" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47782" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47782 |
|
| notation |
CDR0000740778 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
vecuronium bromide |
|
| tui |
T109 T121 |