loading...| Preferred Name |
silver sulfadiazine |
|
| Synonyms |
Thermazene |
|
| Definitions |
A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66567" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66567" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000717602 |
|
| altLabel |
Thermazene Flamazine SSD Silvadene sulfadiazine silver |
|
| CAS Registry |
22199-08-2 |
|
| cui |
C0723730 C0728768 C0037134 C0729114 C0723179 |
|
| DATE FIRST PUBLISHED |
2011-11-17 |
|
| Date last modified |
2011-12-06 |
|
| definition |
A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66567" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66567" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C66567 |
|
| notation |
CDR0000717602 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
silver sulfadiazine |
|
| tui |
T109 T121 |