Preferred Name |
nevirapine |
|
Synonyms |
BIRG 0587 |
|
Definitions |
A non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against human immunodeficiency virus 1. Nevirapine binds directly to the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29277" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29277" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000712787 |
|
altLabel |
BIRG 0587 NVP 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one Viramune |
|
CAS Registry |
129618-40-2 |
|
cui |
C0733416 C0132326 C0728726 |
|
DATE FIRST PUBLISHED |
2011-09-26 |
|
Date last modified |
2011-09-26 |
|
definition |
A non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against human immunodeficiency virus 1. Nevirapine binds directly to the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29277" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29277" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C29277 |
|
notation |
CDR0000712787 |
|
NSC Code |
641530 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
nevirapine |
|
tui |
T109 T114 T121 |