Preferred Name |
phenoxybenzamine hydrochloride |
|
Synonyms |
Dibenzyline |
|
Definitions |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C44435" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C44435" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000703206 |
|
altLabel |
Dibenzyline N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine |
|
CAS Registry |
63-92-3 |
|
cui |
C0031441 C0701367 C0242430 |
|
DATE FIRST PUBLISHED |
2011-06-30 |
|
Date last modified |
2011-06-30 |
|
definition |
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C44435" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C44435" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C44435 |
|
notation |
CDR0000703206 |
|
NSC Code |
37448 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
phenoxybenzamine hydrochloride |
|
tui |
T109 T121 |