loading...| Preferred Name |
carvedilol |
|
| Synonyms |
Coreg |
|
| Definitions |
A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000700417 |
|
| altLabel |
Coreg |
|
| CAS Registry |
72956-09-3 |
|
| cui |
C0719509 C0054836 |
|
| DATE FIRST PUBLISHED |
2011-05-10 |
|
| Date last modified |
2011-05-10 |
|
| definition |
A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. |
|
| LT |
TRD |
|
| notation |
CDR0000700417 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
carvedilol |
|
| tui |
T109 T121 |