Preferred Name |
tigecycline |
|
Synonyms |
Tygacil |
|
Definitions |
A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth. |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000699049 |
|
altLabel |
Tygacil |
|
cui |
C1260298 C1614700 |
|
DATE FIRST PUBLISHED |
2011-04-13 |
|
Date last modified |
2011-04-13 |
|
definition |
A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth. |
|
LT |
TRD |
|
notation |
CDR0000699049 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
tigecycline |
|
tui |
T109 T195 |