Preferred Name |
ramipril |
|
Synonyms |
Altace |
|
Definitions |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29411" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000686948 |
|
altLabel |
Altace |
|
CAS Registry |
87333-19-5 |
|
cui |
C0072973 C0878061 |
|
DATE FIRST PUBLISHED |
2010-10-07 |
|
Date last modified |
2010-10-07 |
|
definition |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29411" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C29411 |
|
notation |
CDR0000686948 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
ramipril |
|
tui |
T109 T121 |