Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

ramipril

Synonyms

Altace

Definitions

A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29411" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000686948

altLabel

Altace

CAS Registry

87333-19-5

cui

C0072973

C0878061

DATE FIRST PUBLISHED

2010-10-07

Date last modified

2010-10-07

definition

A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29411" NCI Thesaurus)

LT

TRD

NCI ID

C29411

notation

CDR0000686948

ORIG STY

Drug/agent

prefLabel

ramipril

tui

T109

T121

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http://purl.jp/bio/4/id/200906061080094006 IOBC LOOM
http://stirdf.jst.go.jp/id/200907036327252679 IOBC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#ramipril SDO LOOM
http://purl.bioontology.org/ontology/MESH/D017257 MESH CUI
http://purl.bioontology.org/ontology/MESH/D017257 MESH CUI
http://purl.bioontology.org/ontology/MESH/D017257 MESH LOOM
http://purl.bioontology.org/ontology/UATC/C09AA05 ATC CUI
http://purl.bioontology.org/ontology/UATC/C09AA05 ATC LOOM
http://purl.bioontology.org/ontology/MSHFRE/D017257 MSHFRE CUI
http://purl.obolibrary.org/obo/CHEBI_8774 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 NIFSTD LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#ramipril FASTO LOOM
http://purl.bioontology.org/ontology/LNC/LP171634-1 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP171634-1 LOINC LOOM
http://purl.obolibrary.org/obo/XCO_0000548 XCO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0072973 OCHV LOOM
http://purl.bioontology.org/ontology/SCTSPA/386872004 SCTSPA CUI
http://www.drugbank.ca/drugs/DB00178 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14736 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386872004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386872004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019562 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019562 VANDF LOOM
http://bmi.utah.edu/ontologies/hfontology/C0072973 HFO LOOM
http://purl.bioontology.org/ontology/RXNORM/35296 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/35296 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/35296 RXNORM LOOM
http://www.semanticweb.org/ontologies/STO.owl#f755b006_ddd3_4b8a_a155_5e3d704d69be CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#f755b006_ddd3_4b8a_a155_5e3d704d69be STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.750 RH-MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#ramipril ADO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29411 NCIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147662 ODAE LOOM
http://purl.bioontology.org/ontology/SCTSPA/108564000 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108564000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/003585 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/003585 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/x02tS RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017257 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007202 NDFRT CUI
http://purl.bioontology.org/ontology/RCD/bi6.. RCD CUI
http://purl.bioontology.org/ontology/RCD/bi6.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147662 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147662 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/262418 RXNORM CUI
http://www.co-ode.org/ontologies/galen#Ramipril GALEN LOOM