Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

doxycycline hyclate injection

Synonyms

Doxycycline Hyclate

Definitions

The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29007" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000669084

altLabel

Doxycycline Hyclate

CAS Registry

24390-14-5

cui

C4086253

C0058731

DATE FIRST PUBLISHED

2010-03-23

Date last modified

2016-01-25

definition

The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29007" NCI Thesaurus)

NCI ID

C29007

notation

CDR0000669084

ORIG STY

Drug/agent

prefLabel

doxycycline hyclate injection

tui

T109

T200

T195

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http://purl.bioontology.org/ontology/VANDF/4017738 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-55022 SNMI CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179116 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/002750 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146105 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/23663 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/71417000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/71417000 SCTSPA CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125186 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125186 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D004318 MESH CUI