loading...| Preferred Name |
doxycycline hyclate injection |
|
| Synonyms |
Doxycycline Hyclate |
|
| Definitions |
The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29007" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000669084 |
|
| altLabel |
Doxycycline Hyclate |
|
| CAS Registry |
24390-14-5 |
|
| cui |
C0058731 C4086253 |
|
| DATE FIRST PUBLISHED |
2010-03-23 |
|
| Date last modified |
2016-01-25 |
|
| definition |
The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29007" NCI Thesaurus) |
|
| NCI ID |
C29007 |
|
| notation |
CDR0000669084 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
doxycycline hyclate injection |
|
| tui |
T109 T195 T200 |