Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

limonene

Synonyms

4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene

Definitions

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000664042

altLabel

4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene

1-methyl-4-prop-1-en-2-yl-cyclohexene

cui

C0064992

DATE FIRST PUBLISHED

2010-01-19

Date last modified

2010-09-20

definition

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus)

NCI ID

C68543

notation

CDR0000664042

ORIG STY

Drug/agent

prefLabel

limonene

tui

T109

T121

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http://purl.obolibrary.org/obo/CHEBI_15384 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_15384 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 CHEBI LOOM
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI LOOM
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http://purl.bioontology.org/ontology/RCD/X79EZ RCD LOOM
http://purl.bioontology.org/ontology/NDDF/007167 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/007167 NDDF LOOM
http://stirdf.jst.go.jp/id/200907004949773006 IOBC LOOM
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