Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

limonene

Synonyms

1-methyl-4-prop-1-en-2-yl-cyclohexene

Definitions

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000664042

altLabel

1-methyl-4-prop-1-en-2-yl-cyclohexene

4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene

cui

C0064992

DATE FIRST PUBLISHED

2010-01-19

Date last modified

2010-09-20

definition

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus)

NCI ID

C68543

notation

CDR0000664042

ORIG STY

Drug/agent

prefLabel

limonene

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000179167 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D000077222 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/411238006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/11038000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/X79EZ RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/11038000 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4018436 VANDF CUI
http://purl.bioontology.org/ontology/RCD/X80BU RCD CUI
http://purl.bioontology.org/ontology/RXNORM/28730 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/411238006 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/007167 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146762 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077222 MSHFRE CUI
http://purl.obolibrary.org/obo/CHEBI_15384 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 GO-PLUS LOOM
http://purl.bioontology.org/ontology/RXNORM/1426477 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/1426476 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907010163633715 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D000077222 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1426777 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C61714 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/11038000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/X79EZ RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C008281 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14289 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/28730 RXNORM LOOM
http://purl.jp/bio/4/id/200906023325459561 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C61709 BERO LOOM
http://purl.obolibrary.org/obo/UPa_UPC06078 UPA LOOM
http://purl.bioontology.org/ontology/RXNORM/1363991 RXNORM LOOM
http://purl.jp/bio/4/id/200906090981614033 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/007167 NDDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61714 NCIT LOOM
http://purl.obolibrary.org/obo/SIBO_0000359 SIBO LOOM
http://stirdf.jst.go.jp/id/200907004949773006 IOBC LOOM
http://purl.obolibrary.org/obo/SIBO_0000223 SIBO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0064992 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61709 NCIT LOOM