Preferred Name |
cefazolin sodium |
|
Synonyms |
Kefzol |
|
Definitions |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000640180 |
|
altLabel |
Kefzol (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, sodium salt Ancef SKF 41558 |
|
CAS Registry |
27164-46-1 |
|
cui |
C0700926 C0700925 C2720180 C0700526 |
|
DATE FIRST PUBLISHED |
2009-04-06 |
|
Date last modified |
2009-04-06 |
|
definition |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C47968 |
|
notation |
CDR0000640180 |
|
NSC Code |
291561 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
cefazolin sodium |
|
tui |
T109 T195 |