Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

cefazolin sodium

Synonyms

Kefzol

Definitions

The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000640180

altLabel

Kefzol

(6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, sodium salt

Ancef

SKF 41558

CAS Registry

27164-46-1

cui

C0700926

C0700925

C2720180

C0700526

DATE FIRST PUBLISHED

2009-04-06

Date last modified

2009-04-06

definition

The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus)

LT

TRD

NCI ID

C47968

notation

CDR0000640180

NSC Code

291561

ORIG STY

Drug/agent

prefLabel

cefazolin sodium

tui

T109

T195

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D002437 MESH CUI
http://purl.bioontology.org/ontology/RCD/x02gG RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179620 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/D002437 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/203171 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000145848 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D002437 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-53121 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/80972005 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/80972005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4017460 VANDF CUI
http://purl.bioontology.org/ontology/NDDF/002720 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D002437 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/203171 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C47968 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145848 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_3483 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3483 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3483 CHEBI LOOM
http://purl.jp/bio/4/id/200906096147275904 IOBC LOOM
http://www.co-ode.org/ontologies/galen#CefazolinSodium GALEN LOOM
http://stirdf.jst.go.jp/id/200907085356468240 IOBC LOOM
http://id.nlm.nih.gov/mesh/D002437 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/80972005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4017460 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/002720 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0700526 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47968 NCIT LOOM