loading...| Preferred Name |
levonorgestrel |
|
| Synonyms |
18-Methylnorethisterone |
|
| Definitions |
The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47585" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47585" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000534399 |
|
| altLabel |
18-Methylnorethisterone 13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one D-(-)-Norgestrel Plan B (17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Norplant |
|
| CAS Registry |
797-63-7 |
|
| cui |
C0876128 C0023566 C1145675 |
|
| DATE FIRST PUBLISHED |
2007-02-22 |
|
| definition |
The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47585" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47585" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47585 |
|
| notation |
CDR0000534399 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
levonorgestrel |
|
| tui |
T125 T109 T121 |