Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

digoxin

Synonyms

Lanoxin

Definitions

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28990" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28990" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000485249

altLabel

Lanoxin

cui

C0699988

C0012265

DATE FIRST PUBLISHED

2006-05-11

definition

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28990" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28990" NCI Thesaurus)

LT

TRD

NCI ID

C28990

notation

CDR0000485249

ORIG STY

Drug/agent

prefLabel

digoxin

tui

T109

T121

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http://purl.bioontology.org/ontology/CPT/1022259 CPT LOOM
http://purl.obolibrary.org/obo/dinto_2861 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.160.349 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004077 RH-MESH LOOM
http://purl.bioontology.org/ontology/MSHFRE/D004077 MSHFRE CUI
http://sbmi.uth.tmc.edu/ontology/ochv#3946 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 HINO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0012265 HFO LOOM
http://purl.bioontology.org/ontology/CSP/0567-2682 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0567-2682 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/3407 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/3407 RXNORM LOOM
http://d-nb.info/gnd/4012306-6 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000005903 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-80330 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-80330 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018047 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4018047 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/XC0Q2 RCD CUI
http://purl.bioontology.org/ontology/UATC/C01AA05 ATC CUI
http://purl.bioontology.org/ontology/UATC/C01AA05 ATC LOOM
http://purl.obolibrary.org/obo/XCO_0000619 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000619 XCO LOOM
http://purl.bioontology.org/ontology/NDDF/000593 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/000593 NDDF LOOM
http://purl.bioontology.org/ontology/SCTSPA/796001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/796001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/387461009 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/LP14714-7 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP14714-7 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/b11.. RCD CUI
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001804 DMTO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Digoxin APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/x02gw RCD CUI
http://purl.bioontology.org/ontology/MESH/D004077 MESH CUI
http://purl.bioontology.org/ontology/MESH/D004077 MESH CUI
http://purl.bioontology.org/ontology/MESH/D004077 MESH LOOM
http://purl.bioontology.org/ontology/RCD/x02gx RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.580.130.500.436 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907085872788919 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.180.261.436 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28990 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28990 NCIT LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0001804 FASTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146388 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146388 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0337449 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/202988 RXNORM CUI
http://purl.jp/bio/4/id/200906050095521421 IOBC LOOM
http://www.drugbank.ca/drugs/DB00390 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001808 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU001808 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Digoxin GALEN LOOM
http://id.loc.gov/authorities/subjects/sh85037995 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387461009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387461009 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146388 OCVDAE LOOM