loading...| Preferred Name |
denosumab |
|
| Synonyms |
TK-006 |
|
| Definitions |
A humanized monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61313" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61313" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000481348 |
|
| altLabel |
TK-006 Densosumab AMG 162 Prolia Xgeva AMG-162 denosumab biosimilar TK-006 |
|
| cui |
C2917754 C1530450 C4727817 C1690432 C2949325 |
|
| DATE FIRST PUBLISHED |
2006-04-20 |
|
| Date last modified |
2018-07-25 |
|
| definition |
A humanized monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61313" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61313" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61313 |
|
| notation |
CDR0000481348 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
denosumab |
|
| tui |
T116 T129 T121 |