loading...| Preferred Name |
dutasteride |
|
| Synonyms |
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide |
|
| Definitions |
A synthetic 4-azasteroid compound with antiandrogenic activity. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5-alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5α-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5-alpha-reductase isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also active in skin and the liver. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47503" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47503" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000479183 |
|
| altLabel |
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide Avodart Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide GG 745 |
|
| CAS Registry |
164656-23-9 |
|
| cui |
C1170079 C0754659 C0666267 |
|
| DATE FIRST PUBLISHED |
2006-04-07 |
|
| Date last modified |
2008-03-05 |
|
| definition |
A synthetic 4-azasteroid compound with antiandrogenic activity. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5-alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5α-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5-alpha-reductase isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also active in skin and the liver. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47503" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47503" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47503 |
|
| notation |
CDR0000479183 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
dutasteride |
|
| tui |
T109 T121 |