Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

dutasteride

Synonyms

Avodart

Definitions

A synthetic 4-azasteroid compound with antiandrogenic activity. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5-alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5α-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5-alpha-reductase isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also active in skin and the liver. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47503" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47503" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000479183

altLabel

Avodart

GG 745

Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

CAS Registry

164656-23-9

cui

C0666267

C1170079

C0754659

DATE FIRST PUBLISHED

2006-04-07

Date last modified

2008-03-05

definition

A synthetic 4-azasteroid compound with antiandrogenic activity. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5-alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5α-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5-alpha-reductase isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also active in skin and the liver. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47503" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47503" NCI Thesaurus)

LT

TRD

NCI ID

C47503

notation

CDR0000479183

ORIG STY

Drug/agent

prefLabel

dutasteride

tui

T109

T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://purl.bioontology.org/ontology/UATC/G04CB02 ATC CUI
http://purl.bioontology.org/ontology/UATC/G04CB02 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/352453 RXNORM CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108373 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DMTO LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#dutasteride PCAO LOOM
http://purl.bioontology.org/ontology/SCTSPA/385570006 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148790 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148790 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48591 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000010108 NDFRT CUI
http://purl.jp/bio/4/id/200906017639116383 IOBC LOOM
http://stirdf.jst.go.jp/id/200907068774861843 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385570006 SNOMEDCT CUI
http://purl.obolibrary.org/obo/CHEBI_521033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.bioontology.org/ontology/SCTSPA/385572003 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/009824 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/009824 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000068538 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068538 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068538 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068538 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0754659 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385572003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/385572003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021371 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021371 VANDF LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000068538 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068538 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/228790 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/228790 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01126 FTC LOOM