Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

daptomycin

Synonyms

LY146032

Definitions

A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum anitbiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47470" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47470" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000469015

altLabel

LY146032

Cubicin

N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone

CAS Registry

103060-53-3

cui

C1330170

C0918009

C0057144

DATE FIRST PUBLISHED

2006-02-21

Date last modified

2006-07-20

definition

A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum anitbiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47470" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47470" NCI Thesaurus)

LT

TRD

NCI ID

C47470

notation

CDR0000469015

ORIG STY

Drug/agent

prefLabel

daptomycin

tui

T195

T116

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D017576 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D017576 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/406439009 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/404965 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D017576 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000010342 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/22299 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D017576 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/406438001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/406439009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148828 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/406438001 SCTSPA CUI
http://purl.bioontology.org/ontology/ATC/J01XX09 ATC CUI
http://purl.bioontology.org/ontology/LNC/LP33354-9 LOINC CUI
http://purl.bioontology.org/ontology/MESH/D017576 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4021414 VANDF CUI
http://purl.bioontology.org/ontology/NDDF/003222 NDDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU060556 LOINC CUI
http://purl.obolibrary.org/obo/OMIT_0017911 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.365.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D017576 BERO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018775 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.477.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/22299 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.641.270 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/406439009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148828 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907085673140365 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C47470 BERO LOOM
https://go.drugbank.com/drugs/DB00080 MDM LOOM
http://purl.bioontology.org/ontology/ATC/J01XX09 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.345.566.270 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47470 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_600103 GENEPIO LOOM
http://purl.bioontology.org/ontology/LNC/LP33354-9 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148828 ODAE LOOM
http://purl.obolibrary.org/obo/DRON_00014250 ODNAE LOOM
http://purl.bioontology.org/ontology/MESH/D017576 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021414 VANDF LOOM
http://purl.jp/bio/4/id/200906072716879701 IOBC LOOM
http://purl.obolibrary.org/obo/ARO_0000068 ARO LOOM
http://purl.bioontology.org/ontology/NDDF/003222 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017576 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060556 LOINC LOOM