Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

D-cycloserine

Synonyms

(+)-4-Amino-3-isoxazolidinone

Definitions

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47466" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47466" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000469006

altLabel

(+)-4-Amino-3-isoxazolidinone

Seromycin

3-Isoxazolidinone, 4-amino-, d-

Oxamycin

Tisomycin

CAS Registry

68-41-7

cui

C4082376

C0010590

C0701966

DATE FIRST PUBLISHED

2006-02-21

Date last modified

2006-07-20

definition

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47466" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47466" NCI Thesaurus)

LT

TRD

NCI ID

C47466

notation

CDR0000469006

NSC Code

154851

ORIG STY

Drug/agent

prefLabel

D-cycloserine

tui

T195

T116

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http://purl.bioontology.org/ontology/NDFRT/N0000005955 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D003523 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/51334008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D003523 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU062954 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/3007 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/387282000 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/ed2.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147483 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4019284 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D003523 MESH CUI
http://purl.bioontology.org/ontology/LNC/LP15501-7 LOINC CUI
http://purl.bioontology.org/ontology/SNMI/C-55230 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387282000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/002788 NDDF CUI
http://purl.bioontology.org/ontology/ATC/J04AB01 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/51334008 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-C2508 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D003523 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/204225 RXNORM CUI
http://stirdf.jst.go.jp/id/200907091927785655 IOBC LOOM
http://purl.jp/bio/4/id/200906007104522590 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 GO-PLUS LOOM