loading...| Preferred Name |
L-citrulline |
|
| Synonyms |
2-amino-5-(carbamoylamino)pentanoic acid |
|
| Definitions |
A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product . Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53406" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C53406" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000464795 |
|
| altLabel |
2-amino-5-(carbamoylamino)pentanoic acid citrulline |
|
| cui |
C0008864 |
|
| DATE FIRST PUBLISHED |
2006-01-25 |
|
| Date last modified |
2006-06-30 |
|
| definition |
A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product . Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53406" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C53406" NCI Thesaurus) |
|
| NCI ID |
C53406 |
|
| notation |
CDR0000464795 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
L-citrulline |
|
| tui |
T116 T123 T121 |