Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

valsartan

Synonyms

Diovan

Definitions

An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47781" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000464172

altLabel

Diovan

CGP 48933

N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

CAS Registry

137862-53-4

cui

C0719949

C0216784

C0527644

DATE FIRST PUBLISHED

2006-01-25

Date last modified

2006-06-30

definition

An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47781" NCI Thesaurus)

LT

TRD

NCI ID

C47781

notation

CDR0000464172

ORIG STY

Drug/agent

prefLabel

valsartan

tui

T109

T121

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http://purl.bioontology.org/ontology/SCTSPA/386876001 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/x03xa RCD CUI
http://purl.bioontology.org/ontology/RXNORM/69749 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/69749 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/69749 RXNORM LOOM
http://purl.obolibrary.org/obo/DRON_00017695 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4020986 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4020986 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/C09CA03 ATC CUI
http://purl.bioontology.org/ontology/UATC/C09CA03 ATC LOOM
http://purl.bioontology.org/ontology/RCD/bk4.. RCD CUI
http://purl.bioontology.org/ontology/RCD/bk4.. RCD LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 NIFSTD LOOM
http://bmi.utah.edu/ontologies/hfontology/C0216784 HFO LOOM
http://purl.jp/bio/4/id/200906040213256090 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D000068756 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068756 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068756 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068756 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108581009 SNOMEDCT CUI
http://sbmi.uth.tmc.edu/ontology/ochv#21148 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386876001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386876001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SCTSPA/108581009 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006659 NDFRT CUI
http://www.drugbank.ca/drugs/DB00177 FTC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C081489 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 DMTO LOOM
http://www.co-ode.org/ontologies/galen#Valsartan GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/216652 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/LP171649-9 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP171649-9 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47781 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47781 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/006279 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/006279 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0216784 OCHV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148456 OCVDAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148456 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148456 NDFRT LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000068756 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068756 MSHFRE CUI