Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

tadalafil

Synonyms

(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione

Definitions

A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47743" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47743" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000462366

altLabel

(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione

Ic351

Cialis

CAS Registry

171596-29-5

cui

C0967375

C1176316

C0967376

DATE FIRST PUBLISHED

2005-12-22

Date last modified

2009-12-30

definition

A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47743" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47743" NCI Thesaurus)

LT

TRD

NCI ID

C47743

notation

CDR0000462366

ORIG STY

Drug/agent

prefLabel

tadalafil

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000068581 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000010536 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/303263 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068581 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU035872 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/407111005 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/358263 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/407734006 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4021415 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/407111005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP100055-5 LOINC CUI
http://purl.bioontology.org/ontology/ATC/G04BE08 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/407734006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000068581 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068581 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148829 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/009874 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D000068581 MESH CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C1176316 OCHV LOOM
https://go.drugbank.com/drugs/DB00820 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035872 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017696 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/358263 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#55830 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00018685 ODNAE LOOM
http://purl.bioontology.org/ontology/VANDF/4021415 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0001297 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407111005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C47743 BERO LOOM
http://stirdf.jst.go.jp/id/200907003144367870 IOBC LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Tadalafil STMSO LOOM
http://purl.bioontology.org/ontology/LNC/LP100055-5 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/G04BE08 ATC LOOM
http://purl.jp/bio/4/id/200906093341709762 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148829 ODAE LOOM
http://purl.bioontology.org/ontology/MESH/D000068581 MESH LOOM
http://www.drugbank.ca/drugs/DB00820 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C429886 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148829 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D000068581 BERO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47743 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/009874 NDDF LOOM