Preferred Name |
tadalafil |
|
Synonyms |
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione |
|
Definitions |
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47743" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47743" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000462366 |
|
altLabel |
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione Ic351 Cialis |
|
CAS Registry |
171596-29-5 |
|
cui |
C0967375 C1176316 C0967376 |
|
DATE FIRST PUBLISHED |
2005-12-22 |
|
Date last modified |
2009-12-30 |
|
definition |
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47743" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47743" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C47743 |
|
notation |
CDR0000462366 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
tadalafil |
|
tui |
T109 T121 |