loading...| Preferred Name |
levonorgestrel-releasing intrauterine system |
|
| Synonyms |
Mirena |
|
| Definitions |
A long-acting, hormone-releasing, intrauterine device consisting of a small, T-shaped, polyethylene frame and a reservoired synthetic progesterone with progestational and potential antineoplastic activities. After insertion of this system into the uterus, the device slowly and gradually releases the hormone. Levonorgestrel acts by binding to the progesterone receptor in the nuclei of target cells, resulting in transcription activation and an alteration in protein synthesis. Subsequently, luteinizing hormone (LH) activity and ovulation are suppressed. Levonorgestrel may also exhibit antiproliferative activity in endometrial tissue. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52193" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52193" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000459975 |
|
| altLabel |
Mirena LNG-IUS |
|
| cui |
C0591811 C1708694 |
|
| DATE FIRST PUBLISHED |
2005-12-22 |
|
| Date last modified |
2006-01-23 |
|
| definition |
A long-acting, hormone-releasing, intrauterine device consisting of a small, T-shaped, polyethylene frame and a reservoired synthetic progesterone with progestational and potential antineoplastic activities. After insertion of this system into the uterus, the device slowly and gradually releases the hormone. Levonorgestrel acts by binding to the progesterone receptor in the nuclei of target cells, resulting in transcription activation and an alteration in protein synthesis. Subsequently, luteinizing hormone (LH) activity and ovulation are suppressed. Levonorgestrel may also exhibit antiproliferative activity in endometrial tissue. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52193" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52193" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C52193 |
|
| notation |
CDR0000459975 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
levonorgestrel-releasing intrauterine system |
|
| tui |
T109 T203 T121 |