Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

romiplostim

Synonyms

AMG 531

Definitions

A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52183" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52183" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000459753

altLabel

AMG 531

methionyl, 227 amino acid C-terminal immunoglobulin G1 (human Fc fragment) fusion protein with 41 amino acid peptide, dimer

Amgen megakaryopoiesis protein 2

Nplate

cui

C1505595

C2364485

C2364481

DATE FIRST PUBLISHED

2005-12-22

Date last modified

2008-12-11

definition

A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52183" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52183" NCI Thesaurus)

LT

TRD

NCI ID

C52183

notation

CDR0000459753

ORIG STY

Drug/agent

prefLabel

romiplostim

tui

T116

T121

T123

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http://purl.bioontology.org/ontology/RXNORM/805452 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/805452 RXNORM LOOM
http://purl.bioontology.org/ontology/SCTSPA/441077008 SCTSPA CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C488777 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000177934 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000177934 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4028106 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4028106 VANDF LOOM
http://purl.obolibrary.org/obo/DRON_00019123 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/439122000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/439122000 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://purl.obolibrary.org/obo/dinto_DB05332 DINTO LOOM
http://www.drugbank.ca/drugs/DB05332 FTC LOOM
http://purl.bioontology.org/ontology/SCTSPA/439122000 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/012794 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/012794 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/C488777 MESH CUI
http://purl.bioontology.org/ontology/MESH/C488777 MESH CUI
http://purl.bioontology.org/ontology/MESH/C488777 MESH CUI
http://purl.bioontology.org/ontology/MESH/C488777 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/805456 RXNORM CUI
http://purl.jp/bio/4/id/201206025351381390 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/441077008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/UATC/B02BX04 ATC CUI
http://purl.bioontology.org/ontology/UATC/B02BX04 ATC LOOM