Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

AMG 531

Synonyms

Amgen Megakaryopoiesis Protein 2

Definitions

A recombinant protein with megakarypoiesis stimulating activity. AMG 531 mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TPO-R stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459753&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459753&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52183" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000459753

altLabel

Amgen Megakaryopoiesis Protein 2

cui

C1505595

C2364481

DATE FIRST PUBLISHED

2005-12-22

Date last modified

2006-07-26

definition

A recombinant protein with megakarypoiesis stimulating activity. AMG 531 mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TPO-R stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459753&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459753&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52183" NCI Thesaurus)

NCI ID

C52183

notation

CDR0000459753

ORIG STY

Drug/agent

prefLabel

AMG 531

tui

T116

T121

T123

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http://purl.bioontology.org/ontology/RXNORM/805452 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/441077008 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000177934 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4028106 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/439122000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/439122000 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/012794 NDDF CUI
http://purl.bioontology.org/ontology/MESH/C488777 MESH CUI
http://purl.bioontology.org/ontology/MESH/C488777 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/441077008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/UATC/B02BX04 ATC CUI