loading...| Preferred Name |
romiplostim |
|
| Synonyms |
AMG 531 |
|
| Definitions |
A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52183" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52183" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000459753 |
|
| altLabel |
AMG 531 Amgen megakaryopoiesis protein 2 methionyl, 227 amino acid C-terminal immunoglobulin G1 (human Fc fragment) fusion protein with 41 amino acid peptide, dimer Nplate |
|
| cui |
C2364481 C1505595 C2364485 |
|
| DATE FIRST PUBLISHED |
2005-12-22 |
|
| Date last modified |
2008-12-11 |
|
| definition |
A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52183" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52183" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C52183 |
|
| notation |
CDR0000459753 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
romiplostim |
|
| tui |
T116 T123 T121 |