Preferred Name |
simvastatin |
|
Synonyms |
Zocor |
|
Definitions |
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29454" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29454" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000455226 |
|
altLabel |
Zocor |
|
cui |
C0678181 C0074554 |
|
DATE FIRST PUBLISHED |
2005-11-10 |
|
Date last modified |
2006-05-18 |
|
definition |
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29454" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29454" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C29454 |
|
notation |
CDR0000455226 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
simvastatin |
|
tui |
T109 T121 |