Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

abarelix

Synonyms

Plenaxis

Definitions

A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2015" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2015" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000415570

altLabel

Plenaxis

PPI-149

R-3827

CAS Registry

183552-38-7

cui

C1527184

C1174732

C0965390

C0965389

DATE FIRST PUBLISHED

2005-01-13

Date last modified

2005-01-10

definition

A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2015" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2015" NCI Thesaurus)

NCI ID

C2015

notation

CDR0000415570

ORIG STY

Drug/agent

prefLabel

abarelix

tui

T116

T121

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http://purl.bioontology.org/ontology/UATC/L02BX01 ATC CUI
http://purl.bioontology.org/ontology/UATC/L02BX01 ATC LOOM
http://purl.bioontology.org/ontology/SCTSPA/407128008 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/407129000 SNOMEDCT CUI
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Abarelix PCAO LOOM
http://purl.bioontology.org/ontology/RXNORM/301739 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/301739 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2015 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407128008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/407128008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021410 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021410 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_337298 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_337298 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_337298 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_337298 DRON LOOM
http://www.drugbank.ca/drugs/DB00106 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000010339 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148825 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148825 NDFRT LOOM
http://purl.bioontology.org/ontology/SCTSPA/407129000 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/008459 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/008459 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/C423508 MESH CUI
http://purl.bioontology.org/ontology/MESH/C423508 MESH CUI
http://purl.bioontology.org/ontology/MESH/C423508 MESH CUI
http://purl.bioontology.org/ontology/MESH/C423508 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C423508 RH-MESH LOOM