loading...| Preferred Name |
zolpidem tartrate |
|
| Synonyms |
ZPD |
|
| Definitions |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29553" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29553" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000370808 |
|
| altLabel |
ZPD Ambien |
|
| Component of | ||
| cui |
C0724725 C0487782 C0078839 |
|
| DATE FIRST PUBLISHED |
2004-05-28 |
|
| Date last modified |
2008-02-04 |
|
| definition |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29553" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29553" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29553 |
|
| notation |
CDR0000370808 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
zolpidem tartrate |
|
| tui |
T109 T121 |