Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

phentolamine mesylate

Synonyms

Regitine

Definitions

The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38691" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38691" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000360460

altLabel

Regitine

2-[N-p'-tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline monomethanesulfonate

CAS Registry

65-28-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000360461

cui

C0136603

C0733398

DATE FIRST PUBLISHED

2004-03-24

Date last modified

2017-12-13

definition

The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38691" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38691" NCI Thesaurus)

LT

TRD

NCI ID

C38691

notation

CDR0000360460

ORIG STY

Drug/agent

prefLabel

phentolamine mesylate

tui

T109

T121

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