Preferred Name |
phentolamine mesylate |
|
Synonyms |
Regitine |
|
Definitions |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38691" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38691" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000360460 |
|
altLabel |
Regitine 2-[N-p'-tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline monomethanesulfonate |
|
CAS Registry |
65-28-1 |
|
Component of | ||
cui |
C0136603 C0733398 |
|
DATE FIRST PUBLISHED |
2004-03-24 |
|
Date last modified |
2017-12-13 |
|
definition |
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38691" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38691" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C38691 |
|
notation |
CDR0000360460 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
phentolamine mesylate |
|
tui |
T109 T121 |