loading...| Preferred Name |
alprostadil |
|
| Synonyms |
MUSE |
|
| Definitions |
The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28816" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28816" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000360459 |
|
| altLabel |
MUSE prostaglandin E1 PGE1 (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid Caverject |
|
| CAS Registry |
745-65-3 |
|
| Component of | ||
| cui |
C2366566 C0591238 C0002335 |
|
| DATE FIRST PUBLISHED |
2004-03-24 |
|
| Date last modified |
2010-06-10 |
|
| definition |
The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28816" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28816" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28816 |
|
| notation |
CDR0000360459 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
alprostadil |
|
| tui |
T109 T121 |