Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

PEG-interferon alfa-2a

Synonyms

peginterferon alfa-2a

Definitions

A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C33987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C33987" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000335280

altLabel

peginterferon alfa-2a

PEGASYS

PEG-IFNA2a

pegylated interferon alfa-2a

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000335282

cui

C0391001

C1176430

DATE FIRST PUBLISHED

2003-09-24

Date last modified

2015-11-05

definition

A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C33987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C33987" NCI Thesaurus)

LT

TRD

NCI ID

C33987

notation

CDR0000335280

ORIG STY

Drug/agent

prefLabel

PEG-interferon alfa-2a

tui

T109

T116

T129

T121

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000148781 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C100416 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178330 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/009711 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/421559001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/398841009 SCTSPA CUI
http://purl.bioontology.org/ontology/ATC/L03AB11 ATC CUI
http://purl.bioontology.org/ontology/MESH/C100416 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/120608 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/398841009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/421559001 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4021362 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/358338 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148781 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/009711 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/421559001 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB00008 FTC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026161 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C33987 BERO LOOM
http://purl.bioontology.org/ontology/ATC/L03AB11 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C100416 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/C100416 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/120608 RXNORM LOOM
https://go.drugbank.com/drugs/DB00008 MDM LOOM
http://www.ebi.ac.uk/efo/EFO_0010102 EFO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33987 NCIT LOOM
http://purl.obolibrary.org/obo/dinto_DB00008 DINTO LOOM
http://purl.obolibrary.org/obo/DRON_00016951 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00016951 COVID-19 LOOM
http://purl.obolibrary.org/obo/DRON_00016951 DRON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0391001 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4021362 VANDF LOOM