Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

valacyclovir hydrochloride

Synonyms

L-valine ester with 9-((2-hydroxyethoxy)methyl)guanine hydrochloride

Definitions

The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29535" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29535" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000257236

altLabel

L-valine ester with 9-((2-hydroxyethoxy)methyl)guanine hydrochloride

BW-256U87

Valtrex

256U87 hydrochloride

CAS Registry

124832-27-5

cui

C0701514

C0771309

C0592245

Date last modified

2017-12-13

definition

The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29535" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29535" NCI Thesaurus)

Legacy PDQ ID

10591

LT

TRD

NCI ID

C29535

notation

CDR0000257236

ORIG STY

Drug/agent

prefLabel

valacyclovir hydrochloride

tui

T109

T121

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http://purl.bioontology.org/ontology/MESH/D000077483 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077483 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077483 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077483 MSHFRE CUI
http://purl.bioontology.org/ontology/NDDF/005050 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/412325002 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077483 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/236081 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148424 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4020944 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/412325002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/152490 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x02u4 RCD CUI
http://purl.bioontology.org/ontology/CSP/5003-0048 CRISP CUI
http://purl.obolibrary.org/obo/CHEBI_9919 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_9919 CHEBI LOOM
http://purl.jp/bio/4/id/200906003544219257 IOBC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29535 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/236081 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C29535 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148424 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48729 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4020944 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/412325002 SNOMEDCT LOOM