Preferred Name |
valacyclovir hydrochloride |
|
Synonyms |
L-valine ester with 9-((2-hydroxyethoxy)methyl)guanine hydrochloride |
|
Definitions |
The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29535" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29535" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000257236 |
|
altLabel |
L-valine ester with 9-((2-hydroxyethoxy)methyl)guanine hydrochloride BW-256U87 Valtrex 256U87 hydrochloride |
|
CAS Registry |
124832-27-5 |
|
cui |
C0701514 C0771309 C0592245 |
|
Date last modified |
2017-12-13 |
|
definition |
The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29535" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29535" NCI Thesaurus) |
|
Legacy PDQ ID |
10591 |
|
LT |
TRD |
|
NCI ID |
C29535 |
|
notation |
CDR0000257236 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
valacyclovir hydrochloride |
|
tui |
T109 T121 |