mercaptopurine

Leukerin

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C195" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C195" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000043436

Leukerin

Alti-Mercaptopurine

Mercapto-6-purine

BW 57-323H

purine-6-thiol Monohydrate

6-mercaptopurine monohydrate

6 thiohypoxanthine

U-4748

7-mercapto-1,3,4,6-tetrazaindene

6 thiopurine

6MP

Purimethol

6-thiopurine

Puri-Nethol

purine-6-thiol (8CI)

Mern

6-mercaptopurine

6-thioxopurine

Flocofil

Mercaleukim

1,7-Dihydro-6H-purine-6-thione

6H-purine-6-thione, 1,7-dihydro- (9CI)

purine-6-thiol, monohydrate

Leupurin

Azathiopurine

6-MP

WR-2785

Mercaptina

1,7 dihydro-6H-purine-6-thione monohydrate

MP

Purinethiol

Mercapurin

Purinethol

Purixan

6-purinethiol

3H purine-6-thiol

Xaluprine

Ismipur

6112-76-1 (monohydrate)

50-44-2

http://purl.bioontology.org/ontology/PDQ/CDR0000041034

http://purl.bioontology.org/ontology/PDQ/CDR0000041784

http://purl.bioontology.org/ontology/PDQ/CDR0000040908

http://purl.bioontology.org/ontology/PDQ/CDR0000041599

http://purl.bioontology.org/ontology/PDQ/CDR0000038858

http://purl.bioontology.org/ontology/PDQ/CDR0000041813

http://purl.bioontology.org/ontology/PDQ/CDR0000040905

http://purl.bioontology.org/ontology/PDQ/CDR0000038399

http://purl.bioontology.org/ontology/PDQ/CDR0000038311

http://purl.bioontology.org/ontology/PDQ/CDR0000041180

http://purl.bioontology.org/ontology/PDQ/CDR0000040421

http://purl.bioontology.org/ontology/PDQ/CDR0000037834

http://purl.bioontology.org/ontology/PDQ/CDR0000041502

http://purl.bioontology.org/ontology/PDQ/CDR0000039046

http://purl.bioontology.org/ontology/PDQ/CDR0000037927

http://purl.bioontology.org/ontology/PDQ/CDR0000393427

http://purl.bioontology.org/ontology/PDQ/CDR0000041595

http://purl.bioontology.org/ontology/PDQ/CDR0000041471

http://purl.bioontology.org/ontology/PDQ/CDR0000043306

http://purl.bioontology.org/ontology/PDQ/CDR0000041672

http://purl.bioontology.org/ontology/PDQ/CDR0000038862

http://purl.bioontology.org/ontology/PDQ/CDR0000038310

http://purl.bioontology.org/ontology/PDQ/CDR0000393425

http://purl.bioontology.org/ontology/PDQ/CDR0000039689

http://purl.bioontology.org/ontology/PDQ/CDR0000043397

http://purl.bioontology.org/ontology/PDQ/CDR0000040161

http://purl.bioontology.org/ontology/PDQ/CDR0000043398

http://purl.bioontology.org/ontology/PDQ/CDR0000043402

http://purl.bioontology.org/ontology/PDQ/CDR0000041594

http://purl.bioontology.org/ontology/PDQ/CDR0000041065

http://purl.bioontology.org/ontology/PDQ/CDR0000043680

http://purl.bioontology.org/ontology/PDQ/CDR0000039529

http://purl.bioontology.org/ontology/PDQ/CDR0000041609

http://purl.bioontology.org/ontology/PDQ/CDR0000041040

http://purl.bioontology.org/ontology/PDQ/CDR0000041673

http://purl.bioontology.org/ontology/PDQ/CDR0000306480

http://purl.bioontology.org/ontology/PDQ/CDR0000038893

http://purl.bioontology.org/ontology/PDQ/CDR0000038883

http://purl.bioontology.org/ontology/PDQ/CDR0000043297

http://purl.bioontology.org/ontology/PDQ/CDR0000042428

http://purl.bioontology.org/ontology/PDQ/CDR0000043294

http://purl.bioontology.org/ontology/PDQ/CDR0000038288

http://purl.bioontology.org/ontology/PDQ/CDR0000041733

http://purl.bioontology.org/ontology/PDQ/CDR0000042400

http://purl.bioontology.org/ontology/PDQ/CDR0000041493

http://purl.bioontology.org/ontology/PDQ/CDR0000041782

http://purl.bioontology.org/ontology/PDQ/CDR0000041832

http://purl.bioontology.org/ontology/PDQ/CDR0000301638

http://purl.bioontology.org/ontology/PDQ/CDR0000041130

http://purl.bioontology.org/ontology/PDQ/CDR0000393428

http://purl.bioontology.org/ontology/PDQ/CDR0000041497

http://purl.bioontology.org/ontology/PDQ/CDR0000042394

http://purl.bioontology.org/ontology/PDQ/CDR0000043681

http://purl.bioontology.org/ontology/PDQ/CDR0000038884

http://purl.bioontology.org/ontology/PDQ/CDR0000042396

http://purl.bioontology.org/ontology/PDQ/CDR0000041783

http://purl.bioontology.org/ontology/PDQ/CDR0000041726

http://purl.bioontology.org/ontology/PDQ/CDR0000042344

http://purl.bioontology.org/ontology/PDQ/CDR0000042283

http://purl.bioontology.org/ontology/PDQ/CDR0000043307

http://purl.bioontology.org/ontology/PDQ/CDR0000038876

http://purl.bioontology.org/ontology/PDQ/CDR0000039415

http://purl.bioontology.org/ontology/PDQ/CDR0000380935

http://purl.bioontology.org/ontology/PDQ/CDR0000041490

http://purl.bioontology.org/ontology/PDQ/CDR0000039660

http://purl.bioontology.org/ontology/PDQ/CDR0000043298

http://purl.bioontology.org/ontology/PDQ/CDR0000039068

http://purl.bioontology.org/ontology/PDQ/CDR0000416131

http://purl.bioontology.org/ontology/PDQ/CDR0000041033

http://purl.bioontology.org/ontology/PDQ/CDR0000040410

http://purl.bioontology.org/ontology/PDQ/CDR0000040353

http://purl.bioontology.org/ontology/PDQ/CDR0000038373

http://purl.bioontology.org/ontology/PDQ/CDR0000038297

http://purl.bioontology.org/ontology/PDQ/CDR0000038851

http://purl.bioontology.org/ontology/PDQ/CDR0000043404

http://purl.bioontology.org/ontology/PDQ/CDR0000043400

http://purl.bioontology.org/ontology/PDQ/CDR0000041496

http://purl.bioontology.org/ontology/PDQ/CDR0000041732

http://purl.bioontology.org/ontology/PDQ/CDR0000040986

http://purl.bioontology.org/ontology/PDQ/CDR0000042395

http://purl.bioontology.org/ontology/PDQ/CDR0000041495

http://purl.bioontology.org/ontology/PDQ/CDR0000038284

http://purl.bioontology.org/ontology/PDQ/CDR0000041182

http://purl.bioontology.org/ontology/PDQ/CDR0000039533

http://purl.bioontology.org/ontology/PDQ/CDR0000306483

http://purl.bioontology.org/ontology/PDQ/CDR0000041734

http://purl.bioontology.org/ontology/PDQ/CDR0000043726

http://purl.bioontology.org/ontology/PDQ/CDR0000039820

http://purl.bioontology.org/ontology/PDQ/CDR0000041833

http://purl.bioontology.org/ontology/PDQ/CDR0000039683

http://purl.bioontology.org/ontology/PDQ/CDR0000041222

http://purl.bioontology.org/ontology/PDQ/CDR0000042350

http://purl.bioontology.org/ontology/PDQ/CDR0000039384

http://purl.bioontology.org/ontology/PDQ/CDR0000041498

http://purl.bioontology.org/ontology/PDQ/CDR0000039596

http://purl.bioontology.org/ontology/PDQ/CDR0000042413

http://purl.bioontology.org/ontology/PDQ/CDR0000038859

http://purl.bioontology.org/ontology/PDQ/CDR0000042462

http://purl.bioontology.org/ontology/PDQ/CDR0000042397

http://purl.bioontology.org/ontology/PDQ/CDR0000041465

http://purl.bioontology.org/ontology/PDQ/CDR0000041129

http://purl.bioontology.org/ontology/PDQ/CDR0000038400

http://purl.bioontology.org/ontology/PDQ/CDR0000043005

http://purl.bioontology.org/ontology/PDQ/CDR0000041491

C0722911

C0000618

C3819063

C1513134

C0729098

C1513135

C0729099

C1455642

C1522533

C1513139

C1513137

C1513138

C1513136

C0729100

C3827179

C0917847

C1522534

C0886849

2014-05-01

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C195" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C195" NCI Thesaurus)

24850

1226

858

TRD

C195

CDR0000043436

755

Drug/agent

mercaptopurine

T109

T114

T121