Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

mechlorethamine hydrochloride

Synonyms

chlorethazine hydrochloride

Definitions

The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C627" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C627" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043434

altLabel

chlorethazine hydrochloride

Mustargen

WR-147650

Caryolysine

N-Lost

Erasol

chlorethamine HCl

mustine

mustargen HCl

chloromethine HCl

methylbis(beta-chloroethyl)amine hydrochloride

Mustine Hydrochloride

bis(2-chloroethyl)methylamine hydrochloride

chlorethamine hydrochloride

chlormethine hydrochloride

mustargen hydrochloride

Onco-Cloramin

HN 2 hydrochloride

Cloramin

ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl hydrochloride

mechlorethamine HCl

CAS Registry

55-86-7

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000039370

http://purl.bioontology.org/ontology/PDQ/CDR0000041158

http://purl.bioontology.org/ontology/PDQ/CDR0000043723

http://purl.bioontology.org/ontology/PDQ/CDR0000040985

http://purl.bioontology.org/ontology/PDQ/CDR0000039977

http://purl.bioontology.org/ontology/PDQ/CDR0000041508

http://purl.bioontology.org/ontology/PDQ/CDR0000039399

http://purl.bioontology.org/ontology/PDQ/CDR0000040147

http://purl.bioontology.org/ontology/PDQ/CDR0000041030

http://purl.bioontology.org/ontology/PDQ/CDR0000039573

http://purl.bioontology.org/ontology/PDQ/CDR0000039976

http://purl.bioontology.org/ontology/PDQ/CDR0000040282

http://purl.bioontology.org/ontology/PDQ/CDR0000039576

http://purl.bioontology.org/ontology/PDQ/CDR0000041159

http://purl.bioontology.org/ontology/PDQ/CDR0000040936

http://purl.bioontology.org/ontology/PDQ/CDR0000039355

cui

C0701935

C0025033

C0701936

C0917712

C0600266

C1522603

C1518337

C0919295

C1518338

C0007310

Date last modified

2017-12-12

definition

The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C627" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C627" NCI Thesaurus)

Legacy PDQ ID

853

LT

TRD

NCI ID

C627

notation

CDR0000043434

NSC Code

762

ORIG STY

Drug/agent

prefLabel

mechlorethamine hydrochloride

tui

T109

T131

T121

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http://purl.bioontology.org/ontology/NDDF/004816 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387071000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387071000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387071000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/155036 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/155036 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-C1EAE SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/6674 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x01AW RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372692002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4017994 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017994 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146339 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146339 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D008466 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008466 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008466 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008466 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008466 MESH CUI
http://purl.bioontology.org/ontology/UATC/L01AA05 ATC CUI
http://purl.bioontology.org/ontology/CSP/1371-8974 CRISP CUI
http://purl.bioontology.org/ontology/NDDF/002630 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4019808 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-78131 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-78131 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-78131 SNMI LOOM
http://purl.bioontology.org/ontology/SCTSPA/372692002 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006427 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147897 NDFRT CUI
http://purl.obolibrary.org/obo/CHEBI_55368 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_55368 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_55368 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_55368 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_55368 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000179557 NDFRT CUI
http://purl.bioontology.org/ontology/CSP/1371-9348 CRISP CUI
http://purl.bioontology.org/ontology/MSHFRE/D008466 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D008466 MSHFRE CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C627 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C627 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C627 NCIT LOOM
http://purl.bioontology.org/ontology/SCTSPA/29156002 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/387071000 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/281544 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-78130 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/29156002 SNOMEDCT CUI