loading...| Preferred Name |
mechlorethamine hydrochloride |
|
| Synonyms |
ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl hydrochloride |
|
| Definitions |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C627" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C627" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043434 |
|
| altLabel |
ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl hydrochloride chlorethamine hydrochloride Erasol methylbis(beta-chloroethyl)amine hydrochloride Cloramin chlorethazine hydrochloride Caryolysine chlormethine hydrochloride bis(2-chloroethyl)methylamine hydrochloride N-Lost mechlorethamine HCl Onco-Cloramin mustine chlorethamine HCl WR-147650 mustargen HCl chloromethine HCl Mustine Hydrochloride Mustargen HN 2 hydrochloride mustargen hydrochloride |
|
| CAS Registry |
55-86-7 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039576 http://purl.bioontology.org/ontology/PDQ/CDR0000041158 http://purl.bioontology.org/ontology/PDQ/CDR0000040282 http://purl.bioontology.org/ontology/PDQ/CDR0000039976 http://purl.bioontology.org/ontology/PDQ/CDR0000041159 http://purl.bioontology.org/ontology/PDQ/CDR0000039355 http://purl.bioontology.org/ontology/PDQ/CDR0000039573 http://purl.bioontology.org/ontology/PDQ/CDR0000039399 http://purl.bioontology.org/ontology/PDQ/CDR0000039977 http://purl.bioontology.org/ontology/PDQ/CDR0000041508 http://purl.bioontology.org/ontology/PDQ/CDR0000040936 http://purl.bioontology.org/ontology/PDQ/CDR0000040147 http://purl.bioontology.org/ontology/PDQ/CDR0000041030 http://purl.bioontology.org/ontology/PDQ/CDR0000043723 |
|
| cui |
C0701936 C0600266 C0701935 C1522603 C0919295 C1518338 C1518337 C0007310 C0025033 C0917712 |
|
| Date last modified |
2017-12-12 |
|
| definition |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C627" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C627" NCI Thesaurus) |
|
| Legacy PDQ ID |
853 |
|
| LT |
TRD |
|
| NCI ID |
C627 |
|
| notation |
CDR0000043434 |
|
| NSC Code |
762 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mechlorethamine hydrochloride |
|
| tui |
T109 T131 T121 |