Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

cephalexin

Synonyms

Keflex

Definitions

A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C356" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C356" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043417

altLabel

Keflex

CAS Registry

15686-71-2

cui

C0700517

C0007716

definition

A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C356" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C356" NCI Thesaurus)

Legacy PDQ ID

7976

LT

TRD

NCI ID

C356

notation

CDR0000043417

ORIG STY

Drug/agent

prefLabel

cephalexin

tui

T109

T195

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http://purl.bioontology.org/ontology/RXNORM/203167 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/MTHU005030 LOINC CUI
http://purl.bioontology.org/ontology/RCD/x02gF RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/54887004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147185 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006717 NDFRT CUI
http://purl.bioontology.org/ontology/CSP/0199-6901 CRISP CUI
http://purl.bioontology.org/ontology/SCTSPA/387304003 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387304003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D002506 MESH CUI
http://purl.bioontology.org/ontology/RCD/e69.. RCD CUI
http://purl.bioontology.org/ontology/NDDF/002716 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4018891 VANDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D002506 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/LP15264-2 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/2231 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/54887004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-53130 SNMI CUI
http://purl.bioontology.org/ontology/ATC/J01DB01 ATC CUI
http://purl.bioontology.org/ontology/LNC/MTHU005030 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C356 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147185 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.200 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387304003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_3534 GENEPIO LOOM
http://purl.bioontology.org/ontology/MESH/D002506 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2631 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/e69.. RCD LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C356 NCIT LOOM
http://stirdf.jst.go.jp/id/200907098932071827 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015894 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB00567 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D002506 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.200 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002716 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4018891 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0003835 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.200 RH-MESH LOOM
http://purl.jp/bio/4/id/200906004870478765 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP15264-2 LOINC LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Cephalexin STMSO LOOM
http://purl.bioontology.org/ontology/RXNORM/2231 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002506 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-53130 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0007716 OCHV LOOM