tinidazole

Simplotan

A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C890" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C890" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000043288

Simplotan

Fasigyn

TDZ

Tindamax

19387-91-8

http://purl.bioontology.org/ontology/PDQ/CDR0000043289

C1601334

C2350048

C0040263

C0591480

A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C890" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C890" NCI Thesaurus)

7801

TRD

C890

CDR0000043288

Drug/agent

tinidazole

T109

T195

T121