loading...| Preferred Name |
genistein |
|
| Synonyms |
sophoricol |
|
| Definitions |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1113" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1113" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043214 |
|
| altLabel |
sophoricol CI 75610 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one genisteol genisterin Genestein prunetol 4',5,7-trihydroxyisoflavone |
|
| CAS Registry |
446-72-0 |
|
| cui |
C2830174 C0061202 |
|
| Date last modified |
2006-08-07 |
|
| definition |
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1113" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1113" NCI Thesaurus) |
|
| Legacy PDQ ID |
7673 |
|
| NCI ID |
C1113 |
|
| notation |
CDR0000043214 |
|
| NSC Code |
36586 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
genistein |
|
| tui |
T109 T123 T121 |