loading...| Preferred Name |
chlorambucil |
|
| Synonyms |
CB-1348 |
|
| Definitions |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C362" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C362" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043113 |
|
| altLabel |
CB-1348 phenylbutyric acid nitrogen mustard p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid Leukeran WR-139013 CB 1348 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid para-N,N-di(b-chloroethyl)aminophenylbutyric acid p-(N, N-di-2-chloroethyl)aminophenyl butyric acid gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid Chloraminophene Leukoran Leukersan chloroambucil chlorobutin butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl) chlorbutinum CLB N,N-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid Chlorbutin Linfolysin chloraminophen chlorobutine gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid Alti-chlorambucil chlorbutine chlorambucilum Lympholysin benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) CHL 4-[bis(2-chloroethyl)amino]benzenebutanoic acid |
|
| CAS Registry |
305-03-3 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039351 http://purl.bioontology.org/ontology/PDQ/CDR0000039096 http://purl.bioontology.org/ontology/PDQ/CDR0000043263 http://purl.bioontology.org/ontology/PDQ/CDR0000038070 http://purl.bioontology.org/ontology/PDQ/CDR0000043264 http://purl.bioontology.org/ontology/PDQ/CDR0000039586 http://purl.bioontology.org/ontology/PDQ/CDR0000040419 http://purl.bioontology.org/ontology/PDQ/CDR0000039427 http://purl.bioontology.org/ontology/PDQ/CDR0000041148 http://purl.bioontology.org/ontology/PDQ/CDR0000041282 http://purl.bioontology.org/ontology/PDQ/CDR0000039566 http://purl.bioontology.org/ontology/PDQ/CDR0000042038 http://purl.bioontology.org/ontology/PDQ/CDR0000041424 http://purl.bioontology.org/ontology/PDQ/CDR0000043123 http://purl.bioontology.org/ontology/PDQ/CDR0000040338 http://purl.bioontology.org/ontology/PDQ/CDR0000041713 http://purl.bioontology.org/ontology/PDQ/CDR0000041489 |
|
| cui |
C1522698 C0699996 C1516483 C1522697 C0008163 C1522699 C1516482 C0729025 C0729022 |
|
| Date last modified |
2018-02-13 |
|
| definition |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C362" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C362" NCI Thesaurus) |
|
| IND Code |
3074 |
|
| Legacy PDQ ID |
751 |
|
| LT |
TRD |
|
| NCI ID |
C362 |
|
| notation |
CDR0000043113 |
|
| NSC Code |
3088 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
chlorambucil |
|
| tui |
T109 T131 T121 |