Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

raloxifene

Synonyms

Keoxifene

Definitions

A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43109&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43109&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1518" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043109

altLabel

Keoxifene

LY 139481

Evista

[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

RALOX

CAS Registry

84449-90-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038565

http://purl.bioontology.org/ontology/PDQ/CDR0000037842

cui

C0720318

C0752233

C0244404

Date last modified

2006-09-11

definition

A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43109&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43109&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1518" NCI Thesaurus)

Legacy PDQ ID

7502

LT

TRD

NCI ID

C1518

notation

CDR0000043109

ORIG STY

Drug/agent

prefLabel

raloxifene

tui

T109

T121

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http://www.co-ode.org/ontologies/galen#Raloxifene GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/217010 RXNORM CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.150.700.900.775 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00481 FTC LOOM
http://purl.bioontology.org/ontology/UATC/G03XC01 ATC CUI
http://purl.bioontology.org/ontology/UATC/G03XC01 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/007282 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/419530003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020849 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/109029006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/109029006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/x04uj RCD CUI
http://purl.bioontology.org/ontology/VANDF/4024098 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4024098 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.bioontology.org/ontology/LNC/LP171633-3 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP171633-3 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022103 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000022103 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907039651233937 IOBC LOOM
http://stirdf.jst.go.jp/id/200907039651233937 IOBC LOOM
http://stirdf.jst.go.jp/id/200907039651233937 IOBC LOOM
http://stirdf.jst.go.jp/id/200907039651233937 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/5001-0008 CRISP CUI
http://purl.bioontology.org/ontology/CSP/5001-0008 CRISP CUI
http://purl.bioontology.org/ontology/CSP/5001-0008 CRISP LOOM
http://purl.jp/bio/4/id/200906030196047290 IOBC LOOM
http://purl.jp/bio/4/id/200906030196047290 IOBC LOOM
http://purl.jp/bio/4/id/200906030196047290 IOBC LOOM
http://purl.jp/bio/4/id/200906030196047290 IOBC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/72143 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/72143 RXNORM LOOM