Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

raloxifene hydrochloride

Synonyms

Raloxifene HCl

Definitions

The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1762" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1762" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043109

altLabel

Raloxifene HCl

[6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

Optruma

Evista

LY-139481

CAS Registry

82640-04-8

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038565

http://purl.bioontology.org/ontology/PDQ/CDR0000037842

cui

C0720318

C0752233

C1514717

C0618111

Date last modified

2018-05-17

definition

The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1762" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1762" NCI Thesaurus)

Legacy PDQ ID

7502

LT

TRD

NCI ID

C1762

notation

CDR0000043109

NSC Code

706725

ORIG STY

Drug/agent

prefLabel

raloxifene hydrochloride

tui

T109

T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1762 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1762 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/217010 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/395856004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/395856004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148538 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148538 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42396 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_50740 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_50740 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50740 CHEBI LOOM
http://purl.bioontology.org/ontology/RCD/fv1.. RCD CUI
http://purl.bioontology.org/ontology/RCD/fv1.. RCD LOOM
http://purl.jp/bio/4/id/200906064870868850 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH CUI
http://purl.bioontology.org/ontology/MESH/D020849 MESH LOOM
http://stirdf.jst.go.jp/id/200907079846557135 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/x04uj RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/395856004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179572 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4021080 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021080 VANDF LOOM
http://purl.bioontology.org/ontology/MSHFRE/D020849 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D020849 MSHFRE CUI
http://purl.bioontology.org/ontology/CSP/5001-0008 CRISP CUI
http://purl.bioontology.org/ontology/RXNORM/166551 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/166551 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/007283 NDDF CUI
http://www.co-ode.org/ontologies/galen#RaloxifeneHydrochloride GALEN LOOM