Preferred Name |
fulvestrant |
|
Synonyms |
ZD9238 |
|
Definitions |
A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1379" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1379" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043053 |
|
altLabel |
ZD9238 ICI 182,780 Faslodex 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol ICI 182780 ICI182780 |
|
CAS Registry |
129453-61-8 |
|
Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000363600 http://purl.bioontology.org/ontology/PDQ/CDR0000350019 |
|
cui |
C1123005 C0701491 C1522236 C0935916 |
|
Date last modified |
2006-05-18 |
|
definition |
A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1379" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1379" NCI Thesaurus) |
|
Legacy PDQ ID |
7401 |
|
LT |
TRD |
|
NCI ID |
C1379 |
|
notation |
CDR0000043053 |
|
NSC Code |
719276 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
fulvestrant |
|
tui |
T109 T121 |