Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

fulvestrant

Synonyms

ZD9238

Definitions

A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1379" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1379" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043053

altLabel

ZD9238

ICI 182,780

Faslodex

7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol

ICI 182780

ICI182780

CAS Registry

129453-61-8

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000363600

http://purl.bioontology.org/ontology/PDQ/CDR0000350019

http://purl.bioontology.org/ontology/PDQ/CDR0000298864

http://purl.bioontology.org/ontology/PDQ/CDR0000445586

cui

C1123005

C0701491

C1522236

C0935916

Date last modified

2006-05-18

definition

A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1379" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1379" NCI Thesaurus)

Legacy PDQ ID

7401

LT

TRD

NCI ID

C1379

notation

CDR0000043053

NSC Code

719276

ORIG STY

Drug/agent

prefLabel

fulvestrant

tui

T109

T121

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http://purl.bioontology.org/ontology/MESH/D000077267 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/203870 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000010122 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077267 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D000077267 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/282357 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/009642 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/385519002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/385519002 SCTSPA CUI
http://purl.bioontology.org/ontology/ATC/L02BA03 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/404845006 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4021350 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D000077267 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077267 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/404845006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148770 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/282357 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/009642 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385519002 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB00947 FTC LOOM
http://purl.bioontology.org/ontology/ATC/L02BA03 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C1379 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4021350 VANDF LOOM
https://go.drugbank.com/drugs/DB00947 MDM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1379 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D000077267 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026183 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148770 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C070081 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 NIFSTD LOOM