Physician Data Query

Last uploaded: January 31, 2024
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Preferred Name

melphalan hydrochloride
Synonyms

Alkerana
Definitions

A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48002" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48002" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042973
altLabel

Alkerana

Evomela

3-(p-(bis(2-chloroethyl)amino)phenyl)-L-alanine, hydrochloride
CAS Registry

3223-07-2
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041864

http://purl.bioontology.org/ontology/PDQ/CDR0000043529

http://purl.bioontology.org/ontology/PDQ/CDR0000040098

http://purl.bioontology.org/ontology/PDQ/CDR0000037848

http://purl.bioontology.org/ontology/PDQ/CDR0000420822

http://purl.bioontology.org/ontology/PDQ/CDR0000040146

http://purl.bioontology.org/ontology/PDQ/CDR0000039396

http://purl.bioontology.org/ontology/PDQ/CDR0000040807

http://purl.bioontology.org/ontology/PDQ/CDR0000040053

http://purl.bioontology.org/ontology/PDQ/CDR0000039648

http://purl.bioontology.org/ontology/PDQ/CDR0000041165

http://purl.bioontology.org/ontology/PDQ/CDR0000038327

http://purl.bioontology.org/ontology/PDQ/CDR0000041877

http://purl.bioontology.org/ontology/PDQ/CDR0000040951

http://purl.bioontology.org/ontology/PDQ/CDR0000043309

http://purl.bioontology.org/ontology/PDQ/CDR0000039369

http://purl.bioontology.org/ontology/PDQ/CDR0000041722

http://purl.bioontology.org/ontology/PDQ/CDR0000285704

http://purl.bioontology.org/ontology/PDQ/CDR0000039034

http://purl.bioontology.org/ontology/PDQ/CDR0000041641

http://purl.bioontology.org/ontology/PDQ/CDR0000042248

http://purl.bioontology.org/ontology/PDQ/CDR0000039790

http://purl.bioontology.org/ontology/PDQ/CDR0000041861

http://purl.bioontology.org/ontology/PDQ/CDR0000038248

http://purl.bioontology.org/ontology/PDQ/CDR0000042497

http://purl.bioontology.org/ontology/PDQ/CDR0000041208

http://purl.bioontology.org/ontology/PDQ/CDR0000039525

http://purl.bioontology.org/ontology/PDQ/CDR0000043484

http://purl.bioontology.org/ontology/PDQ/CDR0000041723

http://purl.bioontology.org/ontology/PDQ/CDR0000039472

http://purl.bioontology.org/ontology/PDQ/CDR0000043112

http://purl.bioontology.org/ontology/PDQ/CDR0000039783

http://purl.bioontology.org/ontology/PDQ/CDR0000041075

http://purl.bioontology.org/ontology/PDQ/CDR0000043100

http://purl.bioontology.org/ontology/PDQ/CDR0000040059

http://purl.bioontology.org/ontology/PDQ/CDR0000039189

http://purl.bioontology.org/ontology/PDQ/CDR0000357718

http://purl.bioontology.org/ontology/PDQ/CDR0000038326

http://purl.bioontology.org/ontology/PDQ/CDR0000361545

http://purl.bioontology.org/ontology/PDQ/CDR0000040254

http://purl.bioontology.org/ontology/PDQ/CDR0000042098

http://purl.bioontology.org/ontology/PDQ/CDR0000041923

http://purl.bioontology.org/ontology/PDQ/CDR0000043032

http://purl.bioontology.org/ontology/PDQ/CDR0000041138

http://purl.bioontology.org/ontology/PDQ/CDR0000041706

http://purl.bioontology.org/ontology/PDQ/CDR0000371824

http://purl.bioontology.org/ontology/PDQ/CDR0000043268

http://purl.bioontology.org/ontology/PDQ/CDR0000041443

http://purl.bioontology.org/ontology/PDQ/CDR0000038187

http://purl.bioontology.org/ontology/PDQ/CDR0000040151

http://purl.bioontology.org/ontology/PDQ/CDR0000043101

http://purl.bioontology.org/ontology/PDQ/CDR0000041263

http://purl.bioontology.org/ontology/PDQ/CDR0000041463

http://purl.bioontology.org/ontology/PDQ/CDR0000039656

http://purl.bioontology.org/ontology/PDQ/CDR0000039647

http://purl.bioontology.org/ontology/PDQ/CDR0000041634

http://purl.bioontology.org/ontology/PDQ/CDR0000041119

http://purl.bioontology.org/ontology/PDQ/CDR0000039100

http://purl.bioontology.org/ontology/PDQ/CDR0000039697

http://purl.bioontology.org/ontology/PDQ/CDR0000042306

http://purl.bioontology.org/ontology/PDQ/CDR0000039457

http://purl.bioontology.org/ontology/PDQ/CDR0000428485

http://purl.bioontology.org/ontology/PDQ/CDR0000041998

http://purl.bioontology.org/ontology/PDQ/CDR0000041072

http://purl.bioontology.org/ontology/PDQ/CDR0000375588

http://purl.bioontology.org/ontology/PDQ/CDR0000257920

http://purl.bioontology.org/ontology/PDQ/CDR0000042075

http://purl.bioontology.org/ontology/PDQ/CDR0000041468

http://purl.bioontology.org/ontology/PDQ/CDR0000042956

http://purl.bioontology.org/ontology/PDQ/CDR0000042330

http://purl.bioontology.org/ontology/PDQ/CDR0000040494

http://purl.bioontology.org/ontology/PDQ/CDR0000041287

http://purl.bioontology.org/ontology/PDQ/CDR0000042536

http://purl.bioontology.org/ontology/PDQ/CDR0000037959

http://purl.bioontology.org/ontology/PDQ/CDR0000040455

http://purl.bioontology.org/ontology/PDQ/CDR0000039591

http://purl.bioontology.org/ontology/PDQ/CDR0000043139

http://purl.bioontology.org/ontology/PDQ/CDR0000039594

http://purl.bioontology.org/ontology/PDQ/CDR0000039330

http://purl.bioontology.org/ontology/PDQ/CDR0000040126

http://purl.bioontology.org/ontology/PDQ/CDR0000042782

http://purl.bioontology.org/ontology/PDQ/CDR0000038179

http://purl.bioontology.org/ontology/PDQ/CDR0000043245

http://purl.bioontology.org/ontology/PDQ/CDR0000041505

http://purl.bioontology.org/ontology/PDQ/CDR0000040155

http://purl.bioontology.org/ontology/PDQ/CDR0000041922

http://purl.bioontology.org/ontology/PDQ/CDR0000042638

http://purl.bioontology.org/ontology/PDQ/CDR0000040495

http://purl.bioontology.org/ontology/PDQ/CDR0000039572

http://purl.bioontology.org/ontology/PDQ/CDR0000038487

http://purl.bioontology.org/ontology/PDQ/CDR0000437141

http://purl.bioontology.org/ontology/PDQ/CDR0000363810
cui

C1513104

C0771055

C4224874
Date last modified

2018-03-01
definition

A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48002" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48002" NCI Thesaurus)
Legacy PDQ ID

722
LT

TRD
NCI ID

C48002
notation

CDR0000042973
NSC Code

241286
ORIG STY

Drug/agent
prefLabel

melphalan hydrochloride
tui

T109

T116

T121
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