Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

tamoxifen citrate

Synonyms

Nourytam

Definitions

The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42901&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42901&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C855" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042901

altLabel

Nourytam

tamoxifen

Novo-Tamoxifen

Soltamox

Ebefen

Zemide

Tamax

(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine

Jenoxifen

Tamofen

Noltam

(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine

TAM

(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate

Ledertam

Novofen

Fentamox

Oestrifen

Estroxyn

Apo-Tamox

ICI-46474

Tamifen

Gen-Tamoxifen

Tamaxin

Nolvadex

(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)

TMX

Lesporene

Genox

Novaldex

Tamoxifeni Citras

Dignotamoxi

Kessar

Nolgen

Tamizam

Oncotam

Clonoxifen

Emblon

PMS-Tamoxifen

ICI 46,474

Nolvadex-D

1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene

Tamoxasta

CAS Registry

54965-24-1 (citrate)

10540-29-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041106

http://purl.bioontology.org/ontology/PDQ/CDR0000040447

http://purl.bioontology.org/ontology/PDQ/CDR0000042091

http://purl.bioontology.org/ontology/PDQ/CDR0000041136

http://purl.bioontology.org/ontology/PDQ/CDR0000039409

http://purl.bioontology.org/ontology/PDQ/CDR0000039469

http://purl.bioontology.org/ontology/PDQ/CDR0000042368

http://purl.bioontology.org/ontology/PDQ/CDR0000037827

http://purl.bioontology.org/ontology/PDQ/CDR0000041277

http://purl.bioontology.org/ontology/PDQ/CDR0000041319

http://purl.bioontology.org/ontology/PDQ/CDR0000042166

http://purl.bioontology.org/ontology/PDQ/CDR0000039024

http://purl.bioontology.org/ontology/PDQ/CDR0000040837

http://purl.bioontology.org/ontology/PDQ/CDR0000039392

http://purl.bioontology.org/ontology/PDQ/CDR0000433277

http://purl.bioontology.org/ontology/PDQ/CDR0000322249

http://purl.bioontology.org/ontology/PDQ/CDR0000038207

http://purl.bioontology.org/ontology/PDQ/CDR0000043558

http://purl.bioontology.org/ontology/PDQ/CDR0000041622

http://purl.bioontology.org/ontology/PDQ/CDR0000040805

http://purl.bioontology.org/ontology/PDQ/CDR0000039535

http://purl.bioontology.org/ontology/PDQ/CDR0000042647

http://purl.bioontology.org/ontology/PDQ/CDR0000042379

http://purl.bioontology.org/ontology/PDQ/CDR0000043383

http://purl.bioontology.org/ontology/PDQ/CDR0000039791

http://purl.bioontology.org/ontology/PDQ/CDR0000042090

http://purl.bioontology.org/ontology/PDQ/CDR0000041916

http://purl.bioontology.org/ontology/PDQ/CDR0000041611

http://purl.bioontology.org/ontology/PDQ/CDR0000040098

http://purl.bioontology.org/ontology/PDQ/CDR0000042160

http://purl.bioontology.org/ontology/PDQ/CDR0000039527

http://purl.bioontology.org/ontology/PDQ/CDR0000039429

http://purl.bioontology.org/ontology/PDQ/CDR0000039468

http://purl.bioontology.org/ontology/PDQ/CDR0000327787

http://purl.bioontology.org/ontology/PDQ/CDR0000041459

http://purl.bioontology.org/ontology/PDQ/CDR0000042089

http://purl.bioontology.org/ontology/PDQ/CDR0000041098

http://purl.bioontology.org/ontology/PDQ/CDR0000042093

http://purl.bioontology.org/ontology/PDQ/CDR0000039121

http://purl.bioontology.org/ontology/PDQ/CDR0000041046

http://purl.bioontology.org/ontology/PDQ/CDR0000041036

http://purl.bioontology.org/ontology/PDQ/CDR0000039470

http://purl.bioontology.org/ontology/PDQ/CDR0000041372

http://purl.bioontology.org/ontology/PDQ/CDR0000041001

http://purl.bioontology.org/ontology/PDQ/CDR0000043382

http://purl.bioontology.org/ontology/PDQ/CDR0000041038

http://purl.bioontology.org/ontology/PDQ/CDR0000042214

http://purl.bioontology.org/ontology/PDQ/CDR0000041377

http://purl.bioontology.org/ontology/PDQ/CDR0000042023

http://purl.bioontology.org/ontology/PDQ/CDR0000350217

http://purl.bioontology.org/ontology/PDQ/CDR0000041364

http://purl.bioontology.org/ontology/PDQ/CDR0000039534

http://purl.bioontology.org/ontology/PDQ/CDR0000041584

http://purl.bioontology.org/ontology/PDQ/CDR0000041728

http://purl.bioontology.org/ontology/PDQ/CDR0000041332

http://purl.bioontology.org/ontology/PDQ/CDR0000041000

http://purl.bioontology.org/ontology/PDQ/CDR0000039369

http://purl.bioontology.org/ontology/PDQ/CDR0000041458

http://purl.bioontology.org/ontology/PDQ/CDR0000437137

http://purl.bioontology.org/ontology/PDQ/CDR0000042502

http://purl.bioontology.org/ontology/PDQ/CDR0000040448

http://purl.bioontology.org/ontology/PDQ/CDR0000041952

http://purl.bioontology.org/ontology/PDQ/CDR0000041460

http://purl.bioontology.org/ontology/PDQ/CDR0000040150

http://purl.bioontology.org/ontology/PDQ/CDR0000041141

http://purl.bioontology.org/ontology/PDQ/CDR0000042139

http://purl.bioontology.org/ontology/PDQ/CDR0000041260

http://purl.bioontology.org/ontology/PDQ/CDR0000042088

http://purl.bioontology.org/ontology/PDQ/CDR0000039516

http://purl.bioontology.org/ontology/PDQ/CDR0000041478

http://purl.bioontology.org/ontology/PDQ/CDR0000041097

http://purl.bioontology.org/ontology/PDQ/CDR0000042460

http://purl.bioontology.org/ontology/PDQ/CDR0000042092

http://purl.bioontology.org/ontology/PDQ/CDR0000039531

http://purl.bioontology.org/ontology/PDQ/CDR0000041078

http://purl.bioontology.org/ontology/PDQ/CDR0000041895

http://purl.bioontology.org/ontology/PDQ/CDR0000039340

http://purl.bioontology.org/ontology/PDQ/CDR0000039770

http://purl.bioontology.org/ontology/PDQ/CDR0000269106

http://purl.bioontology.org/ontology/PDQ/CDR0000039358

http://purl.bioontology.org/ontology/PDQ/CDR0000042208

http://purl.bioontology.org/ontology/PDQ/CDR0000038209

http://purl.bioontology.org/ontology/PDQ/CDR0000042478

http://purl.bioontology.org/ontology/PDQ/CDR0000041366

http://purl.bioontology.org/ontology/PDQ/CDR0000038886

http://purl.bioontology.org/ontology/PDQ/CDR0000039638

http://purl.bioontology.org/ontology/PDQ/CDR0000039523

http://purl.bioontology.org/ontology/PDQ/CDR0000039655

http://purl.bioontology.org/ontology/PDQ/CDR0000039119

cui

C0039286

C1515207

C0591871

C1515190

C1515197

C1177006

C1515211

C1515203

C1515205

C1515198

C1515200

C1515192

C0591496

C1515199

C0591441

C1515201

C1515208

C1515194

C1515195

C1515189

C1515191

C0700621

C0919390

C1515196

C1515204

C1515210

C1515206

C1515193

C0591901

C0079589

C1515202

C1515209

C0592159

C1515188

Date last modified

2006-09-26

definition

The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42901&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42901&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C855" NCI Thesaurus)

Legacy PDQ ID

673

LT

TRD

NCI ID

C855

notation

CDR0000042901

NSC Code

180973

ORIG STY

Drug/agent

prefLabel

tamoxifen citrate

tui

T109

T121

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http://purl.bioontology.org/ontology/RXNORM/281964 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/004826 NDDF CUI
http://www.co-ode.org/ontologies/galen#TamoxifenCitrate GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/40137 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/40137 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/40137 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/10324 RXNORM CUI
http://purl.bioontology.org/ontology/UATC/L02BA01 ATC CUI
http://purl.bioontology.org/ontology/SNMI/C-781E0 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/75959001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/x02s8 RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007041 NDFRT CUI
http://purl.bioontology.org/ontology/RCD/he4.. RCD CUI
http://purl.bioontology.org/ontology/LNC/LA14344-8 LOINC CUI
http://purl.bioontology.org/ontology/RCD/x02l6 RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373345002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4018462 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4018462 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/41395001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/41395001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/x02l4 RCD CUI
http://purl.bioontology.org/ontology/CSP/0119-1179 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0119-1179 CRISP CUI
http://purl.bioontology.org/ontology/MESH/D013629 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013629 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013629 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013629 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013629 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146786 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146786 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907085179517600 IOBC LOOM
http://stirdf.jst.go.jp/id/200907085179517600 IOBC LOOM
http://stirdf.jst.go.jp/id/200907085179517600 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/x02ll RCD CUI
http://purl.bioontology.org/ontology/NDDF/002670 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002670 NDDF LOOM
http://purl.jp/bio/4/id/200906069474829126 IOBC LOOM
http://purl.jp/bio/4/id/200906069474829126 IOBC LOOM
http://purl.jp/bio/4/id/200906069474829126 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-781E1 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-781E1 SNMI LOOM
http://purl.bioontology.org/ontology/RCD/x02cR RCD CUI
http://purl.bioontology.org/ontology/VANDF/4019939 VANDF CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP18484-3 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/498464 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x02bB RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179289 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/MTHU003102 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148024 NDFRT CUI
http://purl.obolibrary.org/obo/CHEBI_9397 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9397 CHEBI LOOM