Definitions |
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C855" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C855" NCI Thesaurus)
|
|
altLabel |
ICI 46,474 (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate Emblon Nolvadex-D Tamoxasta Apo-Tamox Kessar Lesporene Fentamox Noltam Oestrifen Genox (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Nolgen Zemide Gen-Tamoxifen Soltamox ICI-46474 Ledertam Ebefen Novofen TAM Novo-Tamoxifen PMS-Tamoxifen Nourytam Tamaxin Oncotam Dignotamoxi Tamax tamoxifeni citras Tamofen Jenoxifen 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Tamifen Estroxyn Clonoxifen Tamizam
|
|
definition |
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C855" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C855" NCI Thesaurus)
|
|