loading...| Preferred Name |
pilocarpine hydrochloride |
|
| Synonyms |
Salagen |
|
| Definitions |
The hydrochloride salt of a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to the eye, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accomodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62068" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62068" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042876 |
|
| altLabel |
Salagen pilocarpine |
|
| cui |
C0031923 C0770456 C0699930 |
|
| Date last modified |
2006-04-03 |
|
| definition |
The hydrochloride salt of a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to the eye, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accomodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62068" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62068" NCI Thesaurus) |
|
| Legacy PDQ ID |
6689 |
|
| LT |
TRD |
|
| NCI ID |
C62068 |
|
| notation |
CDR0000042876 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
pilocarpine hydrochloride |
|
| tui |
T109 T121 |