loading...| Preferred Name |
gemtuzumab ozogamicin |
|
| Synonyms |
Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody |
|
| Definitions |
A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1806" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1806" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042868 |
|
| altLabel |
Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody CMA 676 CDP-771 CMA-676 WAY-CMA-676 Mylotarg hP67.6-Calicheamicin |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038522 http://purl.bioontology.org/ontology/PDQ/CDR0000269068 http://purl.bioontology.org/ontology/PDQ/CDR0000331877 http://purl.bioontology.org/ontology/PDQ/CDR0000380923 http://purl.bioontology.org/ontology/PDQ/CDR0000361545 http://purl.bioontology.org/ontology/PDQ/CDR0000361540 http://purl.bioontology.org/ontology/PDQ/CDR0000038523 http://purl.bioontology.org/ontology/PDQ/CDR0000038587 |
|
| cui |
C1527091 C0876099 C0677800 C1527090 C1533699 |
|
| Date last modified |
2006-05-09 |
|
| definition |
A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1806" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1806" NCI Thesaurus) |
|
| Legacy PDQ ID |
6678 |
|
| LT |
TRD |
|
| NCI ID |
C1806 |
|
| notation |
CDR0000042868 |
|
| NSC Code |
720568 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
gemtuzumab ozogamicin |
|
| tui |
T116 T129 T121 |