Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

capecitabine

Synonyms

CAPE

Definitions

A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1794" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042852

altLabel

CAPE

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine

Xeloda

Ro 09-1978/000

CAS Registry

154361-50-9

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000331850

http://purl.bioontology.org/ontology/PDQ/CDR0000357578

http://purl.bioontology.org/ontology/PDQ/CDR0000443088

http://purl.bioontology.org/ontology/PDQ/CDR0000043474

http://purl.bioontology.org/ontology/PDQ/CDR0000269071

http://purl.bioontology.org/ontology/PDQ/CDR0000258334

http://purl.bioontology.org/ontology/PDQ/CDR0000378336

http://purl.bioontology.org/ontology/PDQ/CDR0000377677

http://purl.bioontology.org/ontology/PDQ/CDR0000256418

http://purl.bioontology.org/ontology/PDQ/CDR0000352189

http://purl.bioontology.org/ontology/PDQ/CDR0000043545

http://purl.bioontology.org/ontology/PDQ/CDR0000038231

http://purl.bioontology.org/ontology/PDQ/CDR0000410776

http://purl.bioontology.org/ontology/PDQ/CDR0000377335

http://purl.bioontology.org/ontology/PDQ/CDR0000339944

http://purl.bioontology.org/ontology/PDQ/CDR0000369989

http://purl.bioontology.org/ontology/PDQ/CDR0000346919

http://purl.bioontology.org/ontology/PDQ/CDR0000037932

http://purl.bioontology.org/ontology/PDQ/CDR0000440124

http://purl.bioontology.org/ontology/PDQ/CDR0000038062

http://purl.bioontology.org/ontology/PDQ/CDR0000038666

http://purl.bioontology.org/ontology/PDQ/CDR0000437138

http://purl.bioontology.org/ontology/PDQ/CDR0000043335

http://purl.bioontology.org/ontology/PDQ/CDR0000038134

http://purl.bioontology.org/ontology/PDQ/CDR0000426427

http://purl.bioontology.org/ontology/PDQ/CDR0000427284

http://purl.bioontology.org/ontology/PDQ/CDR0000038586

http://purl.bioontology.org/ontology/PDQ/CDR0000334874

http://purl.bioontology.org/ontology/PDQ/CDR0000368788

http://purl.bioontology.org/ontology/PDQ/CDR0000391853

http://purl.bioontology.org/ontology/PDQ/CDR0000038541

http://purl.bioontology.org/ontology/PDQ/CDR0000440125

http://purl.bioontology.org/ontology/PDQ/CDR0000038163

http://purl.bioontology.org/ontology/PDQ/CDR0000315581

http://purl.bioontology.org/ontology/PDQ/CDR0000433521

http://purl.bioontology.org/ontology/PDQ/CDR0000043483

http://purl.bioontology.org/ontology/PDQ/CDR0000438791

http://purl.bioontology.org/ontology/PDQ/CDR0000433202

http://purl.bioontology.org/ontology/PDQ/CDR0000301639

http://purl.bioontology.org/ontology/PDQ/CDR0000425597

http://purl.bioontology.org/ontology/PDQ/CDR0000389265

http://purl.bioontology.org/ontology/PDQ/CDR0000374717

http://purl.bioontology.org/ontology/PDQ/CDR0000373862

http://purl.bioontology.org/ontology/PDQ/CDR0000362072

cui

C1527087

C0724419

C0671970

Date last modified

2006-05-08

definition

A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1794" NCI Thesaurus)

Legacy PDQ ID

6662

LT

TRD

NCI ID

C1794

notation

CDR0000042852

NSC Code

712807

ORIG STY

Drug/agent

prefLabel

capecitabine

tui

T109

T121

T114

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http://sbmi.uth.tmc.edu/ontology/ochv#C0671970 OCHV LOOM
http://purl.bioontology.org/ontology/SCTSPA/108761006 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D000069287 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000069287 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000069287 MESH LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000069287 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005958 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/LA14336-4 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108761006 SNOMEDCT CUI
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001231 HUPSON LOOM
http://purl.bioontology.org/ontology/UATC/L01BC06 ATC CUI
http://purl.bioontology.org/ontology/UATC/L01BC06 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/194000 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/194000 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/194000 NLMVS LOOM
http://stirdf.jst.go.jp/id/200907014108577410 IOBC LOOM
http://purl.jp/bio/4/id/200906036949004326 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148555 ODAE LOOM
http://purl.obolibrary.org/obo/DRON_00010402 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00010402 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00010402 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148555 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148555 NDFRT LOOM
http://purl.bioontology.org/ontology/SCTSPA/386906001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386906001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386906001 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB01101 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/007533 NDDF CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794 ROO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42556 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/220961 RXNORM CUI
http://www.co-ode.org/ontologies/galen#Capecitabine GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4021099 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021099 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C110904 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 NIFSTD LOOM