loading...| Preferred Name |
streptozocin |
|
| Synonyms |
Zanosar |
|
| Definitions |
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C845" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042831 |
|
| altLabel |
Zanosar STZ 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose SZC streptozotocin 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose U-9889 SZN |
|
| CAS Registry |
18883-66-4 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039125 http://purl.bioontology.org/ontology/PDQ/CDR0000039336 http://purl.bioontology.org/ontology/PDQ/CDR0000039654 http://purl.bioontology.org/ontology/PDQ/CDR0000039374 http://purl.bioontology.org/ontology/PDQ/CDR0000041668 http://purl.bioontology.org/ontology/PDQ/CDR0000043159 http://purl.bioontology.org/ontology/PDQ/CDR0000039124 http://purl.bioontology.org/ontology/PDQ/CDR0000039405 http://purl.bioontology.org/ontology/PDQ/CDR0000038880 http://purl.bioontology.org/ontology/PDQ/CDR0000039406 http://purl.bioontology.org/ontology/PDQ/CDR0000039606 |
|
| cui |
C0729061 C0724450 C0038432 |
|
| Date last modified |
2006-09-26 |
|
| definition |
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C845" NCI Thesaurus) |
|
| IND Code |
3859 |
|
| Legacy PDQ ID |
663 |
|
| LT |
TRD |
|
| NCI ID |
C845 |
|
| notation |
CDR0000042831 |
|
| NSC Code |
85998 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
streptozocin |
|
| tui |
T109 T195 |