loading...| Preferred Name |
aminolevulinic acid hydrochloride |
|
| Synonyms |
5-amino-4-oxopentanoic acid HCl |
|
| Definitions |
A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid hydrochloride (ALA HCl) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1849" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1849" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042648 |
|
| altLabel |
5-amino-4-oxopentanoic acid HCl delta-aminolevulinic acid HCl delta-aminolevulinic acid hydrochloride amino-levulinic acid hydrochloride 5-Amino-4-oxopentanoic Acid Hydrochloride ALA HCl aminolevulinic acid HCl d-Amino-Levulinic Acid HCl Ameluz 5-ALA HCl Levulan Kerastick |
|
| CAS Registry |
5451-09-2 |
|
| cui |
C3827192 C0876231 C0876066 |
|
| Date last modified |
2018-06-05 |
|
| definition |
A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid hydrochloride (ALA HCl) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1849" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1849" NCI Thesaurus) |
|
| Legacy PDQ ID |
6386 |
|
| LT |
TRD |
|
| NCI ID |
C1849 |
|
| notation |
CDR0000042648 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aminolevulinic acid hydrochloride |
|
| tui |
T109 T121 |