Preferred Name |
penicillamine |
|
Synonyms |
alpha-amino-beta-methyl-beta-mercaptobutyric acid |
|
Definitions |
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C729" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C729" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042546 |
|
altLabel |
alpha-amino-beta-methyl-beta-mercaptobutyric acid Pendramine Sufortan Mercaptyl Atamir D-Penicillamine Depen Cuprimine beta-thiovaline Kelatin Metalcaptase beta,beta-dimethylcysteine D-mercaptovaline Trolovol 3-mercapto-D-valine Distamine Cuprenil Depamine Perdolat Cupripen |
|
CAS Registry |
52-67-5 |
|
Component of | ||
cui |
C0591393 C1518948 C1518943 C0025536 C1518946 C1518945 C1518942 C0719754 C1518944 C0591958 C0699484 C1518947 C0699483 C0030817 |
|
Date last modified |
2006-12-27 |
|
definition |
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C729" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C729" NCI Thesaurus) |
|
Legacy PDQ ID |
6198 |
|
LT |
TRD |
|
NCI ID |
C729 |
|
notation |
CDR0000042546 |
|
NSC Code |
81549 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
penicillamine |
|
tui |
T116 T121 |