loading...| Preferred Name |
arginine butyrate |
|
| Synonyms |
L-arginine, butanoate (3:4) |
|
| Definitions |
The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2570" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2570" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042492 |
|
| altLabel |
L-arginine, butanoate (3:4) VX-105 |
|
| CAS Registry |
80407-72-3 |
|
| Component of | ||
| cui |
C3642303 C0052329 |
|
| Date last modified |
2017-12-11 |
|
| definition |
The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2570" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2570" NCI Thesaurus) |
|
| Legacy PDQ ID |
6032 |
|
| NCI ID |
C2570 |
|
| notation |
CDR0000042492 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
arginine butyrate |
|
| tui |
T116 T121 |