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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C770" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C770" NCI Thesaurus)
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deltadehydrocortisone Ofisolona Predniment PRD Panasol-S 17,21-dihydroxypregna-1,4-diene-3,11,20-trione Paracort 1;2-dehydrocortisone Deltison Prednisonum Deltacortene Prednitone Predicorten Decortisyl PRED Deltra Cortancyl Dacortin deltacortisone delta 1-cortisone Decorton Prednidib Meprosona-F metacortandracin Econosone Promifen Panafcort DeCortin Predicor Prednilonga Adasone 1, 2-dehydrocortisone Delta(1)-Cortisone Prednicort Predeltin Servisone
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definition |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C770" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C770" NCI Thesaurus)
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