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Last uploaded: January 31, 2024

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Preferred Name	thalidomide
Synonyms	N-phthalylglutamic acid imide
Definitions	A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C870" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C870" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000042332
altLabel	N-phthalylglutamic acid imide Kevadon N-(2,6-dioxo-3-piperidyl)phthalimide Talimol Pantosediv 3-phthalimidoglutarimide THAL Distaval Neurosedyn Softenon Thalomid alpha-phthalimidoglutarimide 2,6-dioxo-3-phthalimidopiperidine 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione N-phthaloylglutamimide Sedoval K-17 Contergan
CAS Registry	50-35-1
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000038249 http://purl.bioontology.org/ontology/PDQ/CDR0000363628 http://purl.bioontology.org/ontology/PDQ/CDR0000299016 http://purl.bioontology.org/ontology/PDQ/CDR0000437217 http://purl.bioontology.org/ontology/PDQ/CDR0000388010 http://purl.bioontology.org/ontology/PDQ/CDR0000037859 http://purl.bioontology.org/ontology/PDQ/CDR0000038251 http://purl.bioontology.org/ontology/PDQ/CDR0000430890 http://purl.bioontology.org/ontology/PDQ/CDR0000377679 http://purl.bioontology.org/ontology/PDQ/CDR0000269712 http://purl.bioontology.org/ontology/PDQ/CDR0000038212 http://purl.bioontology.org/ontology/PDQ/CDR0000355356 http://purl.bioontology.org/ontology/PDQ/CDR0000415354 http://purl.bioontology.org/ontology/PDQ/CDR0000038664 http://purl.bioontology.org/ontology/PDQ/CDR0000377675 http://purl.bioontology.org/ontology/PDQ/CDR0000037975 http://purl.bioontology.org/ontology/PDQ/CDR0000038021 http://purl.bioontology.org/ontology/PDQ/CDR0000038597 http://purl.bioontology.org/ontology/PDQ/CDR0000269112 http://purl.bioontology.org/ontology/PDQ/CDR0000433523 http://purl.bioontology.org/ontology/PDQ/CDR0000037965 http://purl.bioontology.org/ontology/PDQ/CDR0000043068 http://purl.bioontology.org/ontology/PDQ/CDR0000038486 http://purl.bioontology.org/ontology/PDQ/CDR0000271194 http://purl.bioontology.org/ontology/PDQ/CDR0000038444 http://purl.bioontology.org/ontology/PDQ/CDR0000377522 http://purl.bioontology.org/ontology/PDQ/CDR0000433525 http://purl.bioontology.org/ontology/PDQ/CDR0000038328 http://purl.bioontology.org/ontology/PDQ/CDR0000363901 http://purl.bioontology.org/ontology/PDQ/CDR0000269052 http://purl.bioontology.org/ontology/PDQ/CDR0000380733 http://purl.bioontology.org/ontology/PDQ/CDR0000043547 http://purl.bioontology.org/ontology/PDQ/CDR0000257824 http://purl.bioontology.org/ontology/PDQ/CDR0000340966 http://purl.bioontology.org/ontology/PDQ/CDR0000375588 http://purl.bioontology.org/ontology/PDQ/CDR0000258357 http://purl.bioontology.org/ontology/PDQ/CDR0000355820 http://purl.bioontology.org/ontology/PDQ/CDR0000437235 http://purl.bioontology.org/ontology/PDQ/CDR0000043337 http://purl.bioontology.org/ontology/PDQ/CDR0000377523 http://purl.bioontology.org/ontology/PDQ/CDR0000038153 http://purl.bioontology.org/ontology/PDQ/CDR0000038177 http://purl.bioontology.org/ontology/PDQ/CDR0000038137 http://purl.bioontology.org/ontology/PDQ/CDR0000305852 http://purl.bioontology.org/ontology/PDQ/CDR0000257906
cui	C1515344 C1515345 C1515342 C0039736 C1515348 C0729006 C1515346 C1515347 C1515343 C0723668
Date last modified	2017-03-01
definition	A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C870" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C870" NCI Thesaurus)
IND Code	48832
Legacy PDQ ID	5584
LT	TRD
NCI ID	C870
notation	CDR0000042332
NSC Code	66847 91729
ORIG STY	Drug/agent
prefLabel	thalidomide
tui	T109 T131 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SCTSPA/404878004	SCTSPA	CUI
http://purl.bioontology.org/ontology/MESH/D013792	MESH	CUI
http://purl.bioontology.org/ontology/SCTSPA/78702007	SCTSPA	CUI
http://purl.bioontology.org/ontology/MESH/D013792	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/10432	RXNORM	CUI
http://purl.bioontology.org/ontology/NDDF/005933	NDDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/78702007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D013792	MSHFRE	CUI
http://purl.bioontology.org/ontology/ATC/L04AX02	ATC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/404878004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148588	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006367	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4021134	VANDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-64085	SNMI	CUI
http://purl.bioontology.org/ontology/CSP/0397-6187	CRISP	CUI
http://purl.bioontology.org/ontology/RXNORM/220239	RXNORM	CUI
http://purl.obolibrary.org/obo/CHEBI_9513	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	CHEBI	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016567	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/MESH/D013792	MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/10432	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0014645	OMIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C870	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/005933	NDDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/78702007	SNOMEDCT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C870	NCIT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148588	ODAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_74947	FIDEO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.805.810.800	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DISDRIV	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DRON	LOOM
http://purl.jp/bio/4/id/200906035965119250	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D013792	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.621.808.800	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.513.750.750	RH-MESH	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass08828d2b_184c_4083_b9f9_8e82ef976a51	WWECA	LOOM
http://purl.bioontology.org/ontology/ATC/L04AX02	ATC	LOOM
http://purl.obolibrary.org/obo/DRON_00015922	ODNAE	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148588	NDFRT	LOOM
http://stirdf.jst.go.jp/id/200907009440214379	IOBC	LOOM
http://www.drugbank.ca/drugs/DB01041	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12148	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Thalidomide	APAONTO	LOOM
https://go.drugbank.com/drugs/DB01041	MDM	LOOM
http://www.projecthalo.com/aura#Thalidomide	AURA	LOOM
http://purl.bioontology.org/ontology/VANDF/4021134	VANDF	LOOM
http://purl.bioontology.org/ontology/npo#NPO_434	NPO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-64085	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013792	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/0397-6187	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039736	OCHV	LOOM