Preferred Name |
amoxicillin |
|
Synonyms |
Utimox |
|
Definitions |
A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C237" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C237" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042310 |
|
altLabel |
Utimox Trimox Wymox Polymox Amoxil AMOX |
|
CAS Registry |
26787-78-0 |
|
Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000429575 |
|
cui |
C0041058 C0700524 C0723903 C0002645 C0740076 C0740069 |
|
definition |
A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C237" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C237" NCI Thesaurus) |
|
Legacy PDQ ID |
5558 |
|
LT |
TRD |
|
NCI ID |
C237 |
|
notation |
CDR0000042310 |
|
NSC Code |
277174 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
amoxicillin |
|
tui |
T109 T195 |