Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

trastuzumab

Synonyms

MOAB HER2

Definitions

A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1647" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1647" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042265

altLabel

MOAB HER2

HER2 monoclonal antibody

trastuzumab biosimilar ABP 980

trastuzumab biosimilar HLX02

trastuzumab biosimilar PF-05280014

Herceptin trastuzumab biosimilar PF-05280014

trastuzumab biosimilar ALT02

monoclonal antibody HER2

PF-05280014

anti-c-erB-2

monoclonal antibody c-erb-2

Ogivri

Herceptin biosimilar PF-05280014

trastuzumab biosimilar SB3

anti-erbB2 monoclonal antibody

ABP 980

anti-c-erbB2 monoclonal antibody

anti-ERB-2

rhuMAb HER2

anti-erbB-2

RO0452317

anti-p185-HER2

anti-HER2/c-erbB2 monoclonal antibody

Herceptin

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000037876

http://purl.bioontology.org/ontology/PDQ/CDR0000361548

http://purl.bioontology.org/ontology/PDQ/CDR0000038009

http://purl.bioontology.org/ontology/PDQ/CDR0000038518

http://purl.bioontology.org/ontology/PDQ/CDR0000038365

http://purl.bioontology.org/ontology/PDQ/CDR0000043558

http://purl.bioontology.org/ontology/PDQ/CDR0000352312

http://purl.bioontology.org/ontology/PDQ/CDR0000038436

http://purl.bioontology.org/ontology/PDQ/CDR0000038640

http://purl.bioontology.org/ontology/PDQ/CDR0000038661

http://purl.bioontology.org/ontology/PDQ/CDR0000038304

http://purl.bioontology.org/ontology/PDQ/CDR0000038594

http://purl.bioontology.org/ontology/PDQ/CDR0000038432

http://purl.bioontology.org/ontology/PDQ/CDR0000357418

http://purl.bioontology.org/ontology/PDQ/CDR0000038062

http://purl.bioontology.org/ontology/PDQ/CDR0000256419

http://purl.bioontology.org/ontology/PDQ/CDR0000378335

http://purl.bioontology.org/ontology/PDQ/CDR0000370025

http://purl.bioontology.org/ontology/PDQ/CDR0000038364

http://purl.bioontology.org/ontology/PDQ/CDR0000426427

http://purl.bioontology.org/ontology/PDQ/CDR0000042466

http://purl.bioontology.org/ontology/PDQ/CDR0000372882

http://purl.bioontology.org/ontology/PDQ/CDR0000042266

http://purl.bioontology.org/ontology/PDQ/CDR0000038369

http://purl.bioontology.org/ontology/PDQ/CDR0000038695

http://purl.bioontology.org/ontology/PDQ/CDR0000445586

http://purl.bioontology.org/ontology/PDQ/CDR0000038435

http://purl.bioontology.org/ontology/PDQ/CDR0000371642

http://purl.bioontology.org/ontology/PDQ/CDR0000038107

http://purl.bioontology.org/ontology/PDQ/CDR0000391853

http://purl.bioontology.org/ontology/PDQ/CDR0000038673

http://purl.bioontology.org/ontology/PDQ/CDR0000037855

http://purl.bioontology.org/ontology/PDQ/CDR0000043391

http://purl.bioontology.org/ontology/PDQ/CDR0000043253

http://purl.bioontology.org/ontology/PDQ/CDR0000329986

http://purl.bioontology.org/ontology/PDQ/CDR0000038261

http://purl.bioontology.org/ontology/PDQ/CDR0000373961

http://purl.bioontology.org/ontology/PDQ/CDR0000043564

http://purl.bioontology.org/ontology/PDQ/CDR0000037990

http://purl.bioontology.org/ontology/PDQ/CDR0000288843

http://purl.bioontology.org/ontology/PDQ/CDR0000038404

http://purl.bioontology.org/ontology/PDQ/CDR0000037969

http://purl.bioontology.org/ontology/PDQ/CDR0000037973

http://purl.bioontology.org/ontology/PDQ/CDR0000373802

http://purl.bioontology.org/ontology/PDQ/CDR0000042465

http://purl.bioontology.org/ontology/PDQ/CDR0000038077

cui

C0338204

C4721641

C4727806

C4087073

C0728747

C3887777

C4727807

C3887778

C4732952

Date last modified

2018-07-26

definition

A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1647" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1647" NCI Thesaurus)

IND Code

6667

Legacy PDQ ID

5512

LT

TRD

NCI ID

C1647

notation

CDR0000042265

NSC Code

688097

ORIG STY

Drug/agent

prefLabel

trastuzumab

tui

T109

T116

T129

T121

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http://purl.bioontology.org/ontology/SCTSPA/387003001 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005608 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C000598430 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068878 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068878 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000068878 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LA14340-6 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/224905 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/224905 RXNORM LOOM
http://purl.bioontology.org/ontology/SCTSPA/327397006 SCTSPA CUI
http://bmi.utah.edu/ontologies/hfontology/C0728747 HFO LOOM
http://purl.bioontology.org/ontology/UATC/L01XC03 ATC CUI
http://purl.bioontology.org/ontology/UATC/L01XC03 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4021140 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021140 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/101306 RXNORM CUI
http://www.drugbank.ca/drugs/DB00072 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1647 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C112748 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00013025 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00013025 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/327397006 SNOMEDCT CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148593 ODAE LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000068878 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068878 MSHFRE CUI
http://purl.obolibrary.org/obo/dinto_DB00072 DINTO LOOM
http://purl.jp/bio/4/id/200906019489166096 IOBC LOOM
http://d-nb.info/gnd/4661821-1 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387003001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387003001 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004971 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004971 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004971 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148593 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148593 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/007663 NDDF CUI
http://data.bnf.fr/ark:/12148/cb14456492g FAST-TOPICAL LOOM